Research Keyword: microbiome dysbiosis

Microbial links to Alzheimer’s disease

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This review examines whether germs like bacteria, fungi, and viruses might play a role in causing Alzheimer’s disease. Scientists have found that certain bacteria from the mouth and gut, fungal infections, and cold sores (herpes viruses) appear more frequently in Alzheimer’s patients and may trigger the brain changes that damage memory and thinking. While the evidence is promising, researchers still need to determine whether these infections actually cause Alzheimer’s or simply make it worse once it develops.

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Oo-No: Ophidiomyces ophidiicola-bacterial interactions and the role of skin lipids in development of ophidiomycosis

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A fungal disease called ophidiomycosis is spreading among wild snakes around the world. This disease is caused by a fungus that interacts with the natural bacteria living on snake skin and with oils naturally produced by the skin. Certain helpful bacteria on snake skin can fight off the fungus by producing special compounds, but when the fungus takes over, it damages these protective bacteria, leading to worse infection. Understanding these interactions could help develop new ways to protect snakes from this emerging disease.

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One for All and All for One: Multikingdom Interplay in Severe Viral Pneumonia

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This editorial discusses how bacteria, viruses, and fungi interact in the lungs during severe pneumonia from COVID-19 or influenza. When mechanically ventilated patients with COVID-19 had bacterial infections detected, their immune systems released more inflammatory chemicals. However, the same pattern was not observed in influenza patients. Understanding how all these microorganisms work together may help doctors better treat these serious lung infections.

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Fluconazole worsened lung inflammation, partly through lung microbiome dysbiosis in mice with ovalbumin-induced asthma

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Fluconazole is an antifungal medication that works well for treating asthma caused by fungal infections, but may actually worsen asthma from other causes. In mice with allergic asthma, fluconazole killed beneficial bacteria and promoted the growth of harmful bacteria that increased inflammation. This study suggests that fluconazole should only be used for fungal-related asthma and careful monitoring is needed if used in patients with regular asthma.

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