mevalonate pathway – mycolab.ai

Towards engineering agaricomycete fungi for terpenoid production

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Mushroom-forming fungi, particularly species like shiitake and oyster mushrooms, naturally produce valuable compounds called terpenoids used in medicines, food, and cosmetics. Scientists are learning to genetically engineer these fungi to produce even larger amounts of these beneficial compounds, potentially making them as important to biotechnology as baker’s yeast and mold have been historically. This could create new sustainable sources for medicinal compounds and industrial chemicals.

Multi-omics analysis of Taiwanofungus gaoligongensis: effects of different cultivation methods on secondary metabolites

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Researchers studied how different growing methods affect the medicinal compounds produced by Taiwanofungus gaoligongensis, a rare fungus. By growing the fungus on different substrates including wood from specific trees, they found that certain growing methods produced much higher levels of beneficial compounds like antcins that have anti-cancer and anti-inflammatory properties. They also identified which genes control the production of these compounds, which could help improve cultivation methods to make the fungus more medicinally valuable.

Multi-omics analysis of Taiwanofungus gaoligongensis: effects of different cultivation methods on secondary metabolites

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Scientists studied a medicinal mushroom called Taiwanofungus gaoligongensis to understand how different growing methods affect the production of beneficial compounds. They found that growing the mushroom in special bags with certain wood substrates produced far more of the valuable compounds (up to 12-fold more) compared to growing it on rice medium. By examining which genes were active in different growing conditions, they discovered how the mushroom’s cells control the production of these medicinal compounds, which could help farmers grow more potent medicinal mushrooms.

Himalayan Mushrooms as a Natural Source of Ergosterol and Vitamin D2: A Review of Nutraceutical and Functional Food Perspectives

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Mushrooms from the Himalayan region are naturally rich in ergosterol, a compound that converts to vitamin D2 when exposed to sunlight or UV light. This review explores how mushrooms can serve as sustainable, plant-based sources of vitamin D to address deficiencies in populations with limited sun exposure. By understanding how environmental factors and UV treatment affect ergosterol levels, scientists can develop enriched mushroom-based foods and supplements with enhanced nutritional benefits.

Transcriptome and Metabolome Integration Reveals the Impact of Fungal Elicitors on Triterpene Accumulation in Sanghuangporus sanghuang

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Researchers studied how special fungal compounds called elicitors can boost the production of healing substances in a medicinal mushroom called Sanghuangporus sanghuang. By analyzing genes and metabolites, they found that adding elicitors increased beneficial compounds like betulinic acid and 2-hydroxyoleanolic acid by up to 114-fold. These findings suggest a practical way to produce more medicinal compounds from this mushroom for health applications.

Transcriptome and Metabolome Integration Reveals the Impact of Fungal Elicitors on Triterpene Accumulation in Sanghuangporus sanghuang

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Scientists studied how a special fungal treatment can boost the production of beneficial compounds in sanghuang mushrooms. Using advanced molecular analysis techniques, they found that the fungal elicitor significantly increased levels of healing compounds called triterpenes. The treated mushrooms produced 114 times more of one specific compound compared to untreated mushrooms. This research shows how we can grow medicinal mushrooms with higher levels of beneficial substances, which could help develop better treatments for various diseases.

Multi-omics analysis of Taiwanofungus gaoligongensis: effects of different cultivation methods on secondary metabolites

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Scientists studied a medicinal mushroom species to understand how different growing methods affect its beneficial compounds. They found that growing the mushroom on specific wood substrates (from cinnamon trees) produced much higher levels of therapeutic compounds compared to rice-based cultivation. Using advanced molecular techniques, they identified the genes responsible for producing these medicinal compounds and how they are controlled, providing insights to improve mushroom cultivation for better health benefits.

Enhancement and Mechanism of Ergosterol Biosynthesis in Termite Ball Fungus Athelia termitophila by Methyl Jasmonate

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Scientists studied how to increase ergosterol production in termite ball fungus, a medicinal fungus used in traditional medicine. By adding methyl jasmonate, a natural signaling molecule, they more than doubled ergosterol content. Ergosterol is used to make vitamin D2 and certain medications for inflammation and cancer. The study identified which genes need to be activated for better ergosterol production, providing insights for creating more effective medical products from fungi.

Adaptive laboratory evolution of Blakeslea trispora under acetoacetanilide stress leads to enhanced β-carotene biosynthesis

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Scientists used a technique called adaptive laboratory evolution to make a fungus called Blakeslea trispora produce much more beta-carotene, a natural compound that converts to vitamin A in the body and has health benefits. By gradually exposing the fungus to increasing levels of a chemical stressor over 16 months, they helped it evolve to produce 45% more beta-carotene. The adapted fungus showed changes in its genes, physical structure, and fat composition that helped it thrive under stress while making more of this valuable compound.

Expression pattern, subcellular localization of Aspergillus oryzae ergosterol synthases, and their effects on ergosterol and fatty acid metabolism

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Researchers studied how Aspergillus oryzae fungi make ergosterol, a key ingredient in fungal cell membranes. They found that this process is much more complex in this mold than in baker’s yeast, with 49 genes involved. By selectively increasing expression of specific genes, they were able to boost ergosterol production by up to 2.3 times, which could have applications in producing fungal-derived medicines and improving fermented foods.

Research Keyword: mevalonate pathway