metabolomics – Page 9

Exploring Psilocybe spp. mycelium and fruiting body chemistry for potential therapeutic compounds

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This study compared the chemical makeup of psilocybin mushroom mycelium (the root-like growth) versus fruiting bodies (the mushrooms themselves) to understand their different therapeutic potential. While fruiting bodies contain much higher levels of psilocybin, the psychoactive compound, mycelium accumulates other beneficial compounds like α-GPC that may enhance cognition and motor function without strong psychedelic effects. This research suggests that mushroom mycelium could be developed as a non-intoxicating therapeutic alternative with its own unique health benefits.

Telomere-to-Telomere Assembly of the Cordyceps militaris CH1 Genome and Integrated Transcriptomic and Metabolomic Analyses Provide New Insights into Cordycepin Biosynthesis Under Light Stress

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Researchers successfully sequenced the complete genome of Cordyceps militaris CH1, a medicinal fungus used in traditional Chinese medicine. By exposing the fungus to light and analyzing gene expression and metabolite changes, they discovered that light stress activates key genes involved in producing cordycepin, the main active medicinal compound. This breakthrough provides a foundation for improving cordycepin production in artificial cultivation, making this valuable medicine more affordable and accessible.

Deciphering the role of traditional flipping crafts in medium-temperature Daqu fermentation: Microbial succession and metabolic phenotypes

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This research explains how traditional flipping techniques during Daqu (a fermentation starter for Chinese Baijiu liquor) improve its quality. By comparing fermented Daqu that was flipped versus unflipped, scientists discovered that flipping creates better conditions for beneficial microorganisms to thrive, leading to more desirable flavors and higher enzyme activity. The findings suggest that flipping works by managing temperature and moisture, creating a simpler but more stable community of beneficial bacteria and fungi that work together to enhance the fermentation process.

Comparative metabolic profiling of the mycelium and fermentation broth of Penicillium restrictum from Peucedanum praeruptorum rhizosphere

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Researchers studied a fungus called Penicillium restrictum found in the roots of QianHu, a traditional Chinese medicine plant. Using advanced chemical analysis, they discovered that this fungus produces important medicinal compounds called coumarins, with peak production around day 4 of growth. The fungus appears to produce even more types of these beneficial compounds than the plant itself, suggesting it could be used to manufacture these medicines more efficiently.

Integrated Transcriptomics and Metabolomics Provide Insight into Degeneration-Related Molecular Mechanisms of Morchella importuna During Repeated Subculturing

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Morel mushrooms (Morchella importuna) lose quality when repeatedly grown from cultured samples, a process called strain degeneration. Scientists found that degenerated strains have lower levels of beneficial compounds called flavonoids, which normally protect mushroom cells from damage. By studying gene expression and metabolite changes, researchers identified a specific gene responsible for making these protective flavonoids, which becomes less active in degenerated strains. This research suggests that avoiding frequent reculturing and maintaining cold storage or adding antioxidants could help preserve healthy morel mushroom strains.

Metabolic fingerprinting to elucidate the biodegradation of phosphonoacetic acid and its impact on Penicillium metabolism

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Scientists studied how three types of mold fungi break down and use a phosphorus-containing compound called phosphonoacetic acid. Using advanced chemical analysis, they identified unique metabolic patterns in each fungal strain depending on whether they were given regular phosphorus or the more challenging phosphonoacetic acid. These findings reveal how fungi adapt their internal chemistry to handle different phosphorus sources and could help identify which fungi are best at breaking down harmful phosphorus-containing chemicals in the environment.

Integration of fungal transcriptomics and metabolomics provides insights into the early interaction between the ORM fungus Tulasnella sp. and the orchid Serapias vomeracea seeds

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This research explores how orchid fungi recognize and respond to orchid seeds before even touching them. Scientists used advanced molecular techniques to track changes in fungal genes and chemical compounds during the early stages of this symbiotic partnership. The findings show that the fungus actively prepares itself to penetrate the seed’s protective barriers, producing special enzymes and metabolites that facilitate this critical interaction for orchid survival.

Omics approaches to investigate pre-symbiotic responses of the mycorrhizal fungus Tulasnella sp. SV6 to the orchid host Serapias vomeracea

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This study examines how a fungus called Tulasnella responds to orchids before they physically touch each other. Researchers grew the fungus near young orchid plants separated by a thin membrane and found that the fungus changed its genes and chemistry significantly, suggesting it somehow detected the orchid’s presence. The fungus increased production of proteins and fats, as if preparing for a partnership with the plant. These findings help us understand how plants and fungi communicate and begin their beneficial relationships.

Anoectochilus roxburghii Extract Extends the Lifespan of Caenorhabditis elegans through Activating the daf-16/FoxO Pathway

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Researchers studied a traditional Asian orchid plant (Anoectochilus roxburghii) and found it can extend the lifespan of laboratory worms by about 16% and help them resist stress from UV light and heat. The plant works by activating a specific genetic pathway that increases the worm’s natural antioxidant defenses, protecting cells from damage. These findings suggest the plant could potentially be developed into anti-aging products for humans.

Chemical clues to infection: A pilot study on the differential secondary metabolite production during the life cycle of selected Cordyceps species

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This study examined two types of parasitic fungi (Cordyceps javanica and Cordyceps blackwelliae) that infect insects, comparing how they kill their hosts and what chemical compounds they produce during infection. Researchers found that each species uses different toxic molecules to infect insects, with C. javanica being more deadly and producing diverse compounds called beauveriolides. By analyzing infected insect corpses, scientists provided the first direct evidence that these toxic compounds are actually made during real infections, not just in laboratory cultures.

Research Keyword: metabolomics