metabolomics – Page 3

A Comprehensive Review of the Diversity of Fungal Secondary Metabolites and Their Emerging Applications in Healthcare and Environment

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Fungi naturally produce complex chemical compounds called secondary metabolites that have powerful effects against diseases and pests. These include well-known medicines like penicillin and compounds that can fight cancer, reduce inflammation, and lower cholesterol. Scientists are now using advanced genetic and biotechnology techniques to increase production of these fungal compounds, making them more available and affordable for medical, agricultural, and environmental applications. This research shows how fungi could be important sources of new medicines and sustainable alternatives to synthetic chemicals.

Nettle (Urtica cannabina L.) polysaccharides as a novel dietary supplement: enhancing systemic antioxidant status via modulation of the gut–liver axis

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This study found that nettle polysaccharides, especially at lower doses, act as a natural supplement that boosts the body’s antioxidant defenses. The supplement works by promoting beneficial bacteria in the gut, which produce helpful metabolites that signal to the liver to enhance protective antioxidant enzymes. These findings suggest nettle polysaccharides could be a promising natural ingredient for health-conscious food products aimed at maintaining metabolic wellness.

Comparative transcriptomics and metabolomics provide insight into degeneration-related physiological mechanisms of Morchella importuna after long-term preservation

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This research studied how to best preserve morel mushroom cultures for long periods without them losing quality. Scientists compared five different storage methods over 7 years and found that storing cultures in nutrient-poor conditions without repeatedly replicating them produced the healthiest mushrooms. The study identified specific genes and metabolic processes that stayed healthy under the best preservation method, offering farmers better ways to maintain morel quality for cultivation.

Fungal Metabolomics: A Comprehensive Approach to Understanding Pathogenesis in Humans and Identifying Potential Therapeutics

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This review explains how scientists use metabolomics—a technique that identifies all chemical compounds in organisms—to understand how fungi cause disease and resist medicines. Fungi produce many different chemicals that help them attack our bodies and survive treatments, but these same chemicals could also be used to create new medicines. By studying these fungal chemicals, researchers can develop better antifungal drugs and understand how fungi manage to evade our immune system.

Physiological Insights into Enhanced Epsilon-Poly-l-Lysine Production Induced by Extract Supplement from Heterogeneous Streptomyces Strain

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Researchers discovered that exposing bacteria that produce epsilon-poly-l-lysine (a natural antimicrobial compound) to extracts from another closely related bacterium dramatically increases production by 2.6-fold. Using advanced analysis techniques, they found that this boost occurs because the extract triggers the bacteria to activate defense mechanisms, rerouting its metabolism to produce more of this antimicrobial compound. This finding could significantly reduce the cost of producing this useful natural preservative for foods and medicines, making it more commercially viable.

MetaFlowTrain: a highly parallelized and modular fluidic system for studying exometabolite-mediated inter-organismal interactions

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Scientists developed MetaFlowTrain, a system that allows them to study how different microorganisms communicate through chemical molecules they produce. The system uses tiny connected chambers with filters that let chemical signals pass between microbes but keep the organisms separated. This tool revealed that bacteria can inhibit fungal growth through their chemical products and showed how soil conditions affect microbial community structure and plant health.

Recent developments of tools for genome and metabolome studies in basidiomycete fungi and their application to natural product research

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Mushrooms and related fungi in the basidiomycete group produce many useful medicines and agricultural chemicals. Scientists have traditionally struggled to study these fungi because they grow slowly and have complex genomes. Recent technological breakthroughs—including faster DNA sequencing and gene-editing tools—are now making it much easier to discover and understand the helpful compounds these fungi produce, potentially leading to new medicines.

A comprehensive review of mycotoxins, their toxicity, and innovative detoxification methods

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Mycotoxins are poisons produced by molds that commonly contaminate foods like grains, nuts, and spices, causing serious health problems in people and animals. This comprehensive review examines how these toxins affect our health, how to detect them in food, and various methods to remove or destroy them. Traditional approaches using biological agents and chemicals work well but are only partially effective, while newer innovative methods using nanoparticles and plant extracts show greater promise for more complete protection of our food supply.

Rice varietal intercropping mediates resistance to rice blast (Magnaporthe oryzae) through core root exudates

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Growing different varieties of rice together can help protect susceptible rice plants from blast disease. When resistant and susceptible rice varieties are planted together, the resistant plants release special chemicals from their roots that help the susceptible plants fight off the fungal disease. Scientists identified four key chemicals—azelaic acid, sebacic acid, betaine, and phenyl acetate—that work together to boost the immune system of susceptible rice plants and directly kill the blast fungus.

Analysis of Volatile Organic Compounds and Comparison of Heat Resistance Related Gene Expression in Pleurotus ostreatus Under Heat Stress

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This study examined how oyster mushrooms respond to high temperatures at different growth stages. Researchers found that young mycelium and mature fruiting bodies use different strategies to survive heat stress, which affects the flavor compounds they produce. Mycelium produces more of certain volatile compounds under heat stress, while fruiting bodies actually lose their characteristic mushroom flavor compound called 1-Octen-3-ol.

Research Keyword: metabolomics