metabolomics – Page 14

Unveiling the Substrate-Dependent Dynamics of Mycotoxin Production in Fusarium verticillioides Using an OSMAC-Metabolomics Approach

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Researchers studied how different growing conditions affect the production of harmful toxins by a fungus called Fusarium verticillioides that contaminates crops. Using advanced chemical analysis techniques, they found that the type of growth medium and time of incubation significantly influenced which toxins the fungus produced and in what amounts. Growing the fungus on corn-based medium produced different toxins than growing it on barley-based medium. These findings can help develop better strategies to prevent mycotoxin contamination in food and animal feed.

Genome-Mining Based Discovery of Pyrrolomycin K and L from the Termite-Associated Micromonospora sp. RB23

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Researchers discovered two new antimicrobial compounds called pyrrolomycins from a bacterium found in termite guts using genome analysis and advanced chemistry techniques. These compounds are modified versions of known antimicrobial molecules, featuring halogenated structures. Interestingly, the bacteria appears to protect itself from its own toxic compounds through chemical modifications, a strategy that researchers believe could inform the design of new antibiotics to combat drug-resistant bacteria.

Comparative Multi-Omics Analysis and Antitumor Activity of Phylloporia crataegi and Phylloporia fontanesiae

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Researchers compared two types of medicinal fungi (Phylloporia crataegi and P. fontanesiae) to understand why one is more effective at fighting cancer. Using advanced molecular analysis techniques, they found that P. crataegi contains higher levels of cancer-fighting compounds and activates more genes related to cancer cell death. These findings suggest that these fungi could be promising sources for developing new cancer treatments.

Metabolomics analysis of mycelial exudates provides insights into fungal antagonists of Armillaria

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This study examined how two types of honey mushrooms (Armillaria) fight each other when grown together. Researchers found specific chemical markers and metabolic pathways that are activated during this competition. The study identified 156 new compounds produced during co-culture, including 32 with potential antifungal properties. These findings could help understand how mushrooms naturally combat fungal pathogens.

A Fungal Endophyte Alters Poplar Leaf Chemistry, Deters Insect Feeding and Shapes Insect Community Assembly

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Researchers discovered that a fungus living inside poplar trees helps protect them from harmful insects by boosting the tree’s own chemical defences and producing its own deterrent compound called stachydrine. In laboratory tests, the fungus successfully deterred leaf-eating insects from feeding on poplar leaves. However, in field studies, the endophyte-infected trees attracted more aphids while repelling beetles, suggesting the fungus affects different types of insects differently depending on how they feed.

Research Keyword: metabolomics

Unveiling the Substrate-Dependent Dynamics of Mycotoxin Production in Fusarium verticillioides Using an OSMAC-Metabolomics Approach

Genome-Mining Based Discovery of Pyrrolomycin K and L from the Termite-Associated Micromonospora sp. RB23

Comparative Multi-Omics Analysis and Antitumor Activity of Phylloporia crataegi and Phylloporia fontanesiae

Metabolomics analysis of mycelial exudates provides insights into fungal antagonists of Armillaria

A Fungal Endophyte Alters Poplar Leaf Chemistry, Deters Insect Feeding and Shapes Insect Community Assembly