metabolomics – Page 10

Transcriptome and Metabolome Integration Reveals the Impact of Fungal Elicitors on Triterpene Accumulation in Sanghuangporus sanghuang

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Researchers studied how special fungal compounds called elicitors can boost the production of healing substances in a medicinal mushroom called Sanghuangporus sanghuang. By analyzing genes and metabolites, they found that adding elicitors increased beneficial compounds like betulinic acid and 2-hydroxyoleanolic acid by up to 114-fold. These findings suggest a practical way to produce more medicinal compounds from this mushroom for health applications.

The putatively high‐altitude adaptation of macaque monkeys: Evidence from the fecal metabolome and gut microbiome

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This study examined how macaque monkeys living on the high Tibetan Plateau adapt to harsh conditions. Researchers found that high-altitude macaques have darker feces containing more stercobilin, a pigment from red blood cell breakdown. Their gut bacteria are specially adapted to process this increased bilirubin from the extra red blood cells produced at high altitude. Interestingly, high-altitude macaques also eat medicinal mushrooms like Ganoderma lucidum, which may help them cope with the stress and low oxygen levels.

Quorum-driven microbial consortium for Bioplastic production from agro-waste

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Scientists created a partnership between a fungus and bacteria to make eco-friendly plastic (PHA) from brewery and cooking waste. The fungus breaks down the tough plant material while the bacteria converts the released compounds into bioplastic. By adding a natural chemical signal (farnesol), they improved the process and scaled it up successfully in a larger reactor without needing expensive pretreatment steps.

Integrated transcriptome and metabolome profiling reveals mechanisms underlying the infection of Cytospora mali in “Jin Hong” branches

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This research examined how apple trees defend themselves against a serious fungal disease called Valsa canker caused by Cytospora mali. Scientists used advanced genetic and chemical analysis techniques to identify which genes and protective compounds are activated when apple branches are infected. They found that healthy apple trees fight the infection by strengthening their cell walls, producing special protective enzymes, and accumulating defense chemicals like α-linolenic acid and betaine. These discoveries could help develop better ways to prevent or manage this destructive disease in apple orchards.

Biodiversity-Driven Natural Products and Bioactive Metabolites

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This comprehensive review explores how diverse organisms like plants, fungi, and marine creatures produce remarkable chemical compounds for survival and defense. These natural products have inspired many modern medicines, but scientists now understand that the chemical diversity comes not just from the organisms themselves but from their ecological interactions and environmental challenges. By studying how these chemicals are made and what triggers their production, researchers can discover new drugs and medicines while protecting the ecosystems that generate them.

Strain and contact-dependent metabolomic reprogramming reveals distinct interaction strategies between Laccaria bicolor and Trichoderma

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Scientists studied how two types of soil fungi interact with each other when grown together in laboratory conditions. By analyzing the chemicals these fungi produce and release, they discovered that the fungi actively communicate and compete with each other in different ways depending on how close they are to each other. The findings show that both airborne chemicals and chemicals released into the soil play important roles in how fungi recognize friends from foes, which could help improve the use of beneficial fungi in agriculture.

Marine Fungal Metabolites: A Promising Source for Antibiofilm Compounds

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Bacteria can form protective layers called biofilms that resist antibiotics, causing serious infections. Scientists are discovering that fungi living in seaweed and marine environments produce natural compounds that can break down these biofilm barriers. This review shows that marine fungi offer promising new alternatives to combat antibiotic-resistant infections, though more research is needed to fully explore their potential.

Transcriptomic and metabolomic analyses unravel the different pathogenic mechanisms of Ustilaginoidea virens in indica and japonica rice

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Rice is vulnerable to a fungal disease called false smut caused by Ustilaginoidea virens. Scientists found that this fungus attacks different rice varieties in different ways. By studying gene expression and chemical changes in infected rice, they discovered that the fungus uses different molecular pathways to infect indica rice versus japonica rice, explaining why these varieties have different levels of resistance to the disease.

Transcriptome and Metabolome Integration Reveals the Impact of Fungal Elicitors on Triterpene Accumulation in Sanghuangporus sanghuang

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Scientists studied how a special fungal treatment can boost the production of beneficial compounds in sanghuang mushrooms. Using advanced molecular analysis techniques, they found that the fungal elicitor significantly increased levels of healing compounds called triterpenes. The treated mushrooms produced 114 times more of one specific compound compared to untreated mushrooms. This research shows how we can grow medicinal mushrooms with higher levels of beneficial substances, which could help develop better treatments for various diseases.

Strain and contact-dependent metabolomic reprogramming reveals distinct interaction strategies between Laccaria bicolor and Trichoderma

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Scientists studied how two types of fungi interact when grown together in the laboratory. They found that different strains of Trichoderma fungi and beneficial mushroom fungi (Laccaria) communicate and compete using chemical signals that vary depending on how close they are to each other. When fungi are far apart, they use airborne chemicals, but when they touch directly, they change their chemical production dramatically. These findings could help improve the use of Trichoderma as biological pest control agents in agriculture.

Research Keyword: metabolomics