metabolomic analysis

Editorial: Raising the bar: advancing therapeutic strategies for fighting communicable and noncommunicable diseases

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Scientists are developing new ways to fight dangerous infections caused by bacteria, viruses, and drug-resistant pathogens. Recent discoveries include safer uses of existing drugs, better dosing strategies tailored to individual patients, and effective combination therapies that reduce antibiotic resistance. These advances represent important progress in treating serious infectious diseases like COVID-19, tuberculosis, and bacterial infections.

The impact of continuous cultivation of Ganoderma lucidum on soil nutrients, enzyme activity, and fruiting body metabolites

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This study examined how growing Ganoderma lucidum (a medicinal mushroom) on the same land for two consecutive years affects the soil and the mushroom’s beneficial compounds. Researchers found that continuous cultivation depleted soil nutrients and reduced enzyme activity, particularly in the top layer of soil. The mushrooms grown in the first year had more beneficial compounds than those grown in the second year, with differences linked to changes in soil quality and microbial activity.

Volatile Organic Compounds Produced by Co-Culture of Burkholderia vietnamiensis B418 with Trichoderma harzianum T11-W Exhibits Improved Antagonistic Activities against Fungal Phytopathogens

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Scientists studied how two beneficial microorganisms (a bacterium and a fungus) work together to produce compounds that kill plant-damaging fungi. When grown together, they produced more protective compounds than when grown separately, showing promise as a natural alternative to chemical fungicides for protecting crops and stored fruits from fungal diseases.

PEG-Mediated Protoplast Transformation of Penicillium sclerotiorum (scaumcx01): Metabolomic Shifts and Root Colonization Dynamics

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Scientists developed a new method to genetically modify a fungus called Penicillium sclerotiorum by using protoplasts, which are fungal cells with their protective outer walls removed. They added a glowing green protein (GFP) to track the fungus and discovered that this modification changed how the fungus uses fats and lipids. When they treated tomato seeds with enzymes before exposing them to the modified fungus, it enhanced the fungus’s ability to colonize plant roots, potentially helping plants grow better.

Strain and contact-dependent metabolomic reprogramming reveals distinct interaction strategies between Laccaria bicolor and Trichoderma

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Scientists studied how two types of fungi interact with each other when grown together. One fungus (Trichoderma) is used as a biocontrol agent to fight harmful fungi, while the other (Laccaria) helps trees grow. By analyzing the chemicals these fungi release both as gases and through their growth medium, researchers found that the fungi communicate and compete with each other differently depending on how close they are. These findings help us understand how fungi interact in soil and could improve the use of biocontrol agents in agriculture.

The serine palmitoyl transferase of plant pathogenic fungi: a promising new target for the development of novel crop protection solutions

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Scientists have discovered a new type of fungicide called pyridazine carboxamides that effectively kill plant-damaging fungi by blocking a key enzyme involved in their cell membrane formation. These compounds work against many common crop diseases like gray mold and leaf spots, though they are less effective against certain wheat pathogens. The research validates this new approach as a promising tool for protecting crops and managing fungicide resistance while maintaining global food security.

Characterization of the gut mycobiome in patients with non-alcoholic fatty liver disease and correlations with serum metabolome

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This study examined fungi in the gut of people with fatty liver disease and found that certain fungal species are more common in diseased patients. By analyzing both gut fungi and blood chemicals, researchers discovered that fungi significantly influence metabolic substances related to liver health. A computer model combining information about gut fungi and bacteria could identify fatty liver disease with reasonable accuracy, suggesting that fungi could be useful for disease diagnosis and potential treatment.

Local Fungi Promote Plant Growth by Positively Affecting Rhizosphere Metabolites to Drive Beneficial Microbial Assembly

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Researchers tested local fungal species from the Qinghai-Tibet Plateau to help plants grow in damaged mining areas at extremely high altitudes. The local fungi were more effective than commercial bacterial products at promoting plant growth and creating healthy soil microbiomes. These fungi work by producing special chemicals that attract beneficial microorganisms while preventing harmful fungi from growing, making them ideal for restoring ecosystems in cold, high-altitude mining regions.

Metabolic fingerprinting to elucidate the biodegradation of phosphonoacetic acid and its impact on Penicillium metabolism

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Scientists studied how three types of mold fungi break down and use a phosphorus-containing compound called phosphonoacetic acid. Using advanced chemical analysis, they identified unique metabolic patterns in each fungal strain depending on whether they were given regular phosphorus or the more challenging phosphonoacetic acid. These findings reveal how fungi adapt their internal chemistry to handle different phosphorus sources and could help identify which fungi are best at breaking down harmful phosphorus-containing chemicals in the environment.

Discovery of the antifungal compound ilicicolin K through genetic activation of the ilicicolin biosynthetic pathway in Trichoderma reesei

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Scientists used genetic engineering to activate a dormant gene cluster in the fungus Trichoderma reesei, enabling it to produce the antifungal compound ilicicolin H in high quantities. During this process, they discovered a new related compound called ilicicolin K that shows even stronger antifungal properties. These compounds could potentially overcome limitations of current antifungal treatments, especially against drug-resistant fungi like Candida auris.

Research Keyword: metabolomic analysis