Research Keyword: metabolite analysis

Cwh8 moonlights as a farnesyl pyrophosphate phosphatase and is essential for farnesol biosynthesis in Candida albicans

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Candida albicans is a common fungus that causes serious infections in people with weakened immune systems. The fungus produces a molecule called farnesol that prevents it from growing in long filaments, which are associated with virulence. Researchers discovered that an enzyme called Cwh8 is absolutely essential for making farnesol, and when this enzyme is missing, the fungus becomes highly sensitive to the antifungal drug fluconazole, suggesting a potential strategy to overcome drug resistance.

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Galacto-Oligosaccharides Exert Bifidogenic Effects at Capsule-Compatible Ultra-Low Doses

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This study tested whether tiny doses of a prebiotic called galacto-oligosaccharides (GOS) could be effective when taken in capsule form instead of large sachets. Researchers used a specially designed laboratory system to simulate how these compounds work in the human gut. Even at the lowest dose tested (0.5 g), the GOS successfully increased beneficial gut bacteria and produced helpful compounds that support digestive health, while producing minimal gas.

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Inhibitory Activity of Shrimp Waste Extracts on Fungal and Oomycete Plant Pathogens

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Researchers discovered that waste from shrimp processing can be converted into a natural fungicide that effectively kills plant-damaging fungi and mold. When applied to oranges, lemons, and apples artificially infected with mold, the shrimp waste extract significantly reduced rot and fruit damage. This finding is important because it offers a more environmentally friendly alternative to chemical fungicides while helping reduce the massive amounts of shrimp processing waste that typically end up in landfills or oceans.

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