Research Keyword: metabolic reprogramming

Physiological Insights into Enhanced Epsilon-Poly-l-Lysine Production Induced by Extract Supplement from Heterogeneous Streptomyces Strain

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Researchers discovered that exposing bacteria that produce epsilon-poly-l-lysine (a natural antimicrobial compound) to extracts from another closely related bacterium dramatically increases production by 2.6-fold. Using advanced analysis techniques, they found that this boost occurs because the extract triggers the bacteria to activate defense mechanisms, rerouting its metabolism to produce more of this antimicrobial compound. This finding could significantly reduce the cost of producing this useful natural preservative for foods and medicines, making it more commercially viable.

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Evaluation of Anticancer Potential of Ganoderma lucidum on MCF-7 Breast Cancer Cells Through Genetic Transcription of Energy Metabolism

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Researchers tested extracts from Ganoderma lucidum (Reishi mushroom) against breast cancer cells in the laboratory. They found that the methanol extract was particularly effective at killing cancer cells while leaving healthy cells relatively unharmed. The mushroom works by disrupting the cancer cells’ metabolism and triggering programmed cell death, making it a promising natural treatment option that could complement conventional cancer therapies.

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Oxaloacetate anaplerosis differently contributes to pathogenicity in plant pathogenic fungi Fusarium graminearum and F. oxysporum

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Two important crop-destroying fungi, Fusarium graminearum and F. oxysporum, rely differently on a metabolic enzyme called pyruvate carboxylase to cause disease. Researchers found that removing this enzyme completely eliminates the ability of F. oxysporum to infect tomato plants by blocking its capacity to penetrate roots and break down plant cell walls. However, the same enzyme deletion has minimal effect on F. graminearum’s ability to infect wheat, suggesting these fungi have evolved different metabolic strategies for attacking their hosts.

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Unveiling molecular mechanisms of strobilurin resistance in the cacao pathogen Moniliophthora perniciosa

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Cacao farmers have struggled to control witches’ broom disease, a fungal infection caused by Moniliophthora perniciosa, because the fungus survives even high doses of strobilurin fungicides. This study reveals how the fungus adapts to the fungicide by switching its metabolism to use alternative energy sources, activating detoxification systems, and using an alternative respiratory pathway. Researchers also discovered that prolonged fungicide exposure can create even more resistant mutants with mutations in genes that control fungal growth and gene expression.

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Unveiling molecular mechanisms of strobilurin resistance in the cacao pathogen Moniliophthora perniciosa

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This research reveals how a fungus that causes disease in cacao plants survives treatment with strobilurin fungicides, which are commonly used in agriculture. Scientists discovered that the fungus adapts by reorganizing its metabolism to compensate for the drug’s effects, activating detoxification systems, and in some cases, developing genetic mutations that enhance resistance. Understanding these survival mechanisms could help develop better strategies to control this economically important crop disease.

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