Research Keyword: metabolic regulation

Edible mushrooms as emerging biofactories for natural therapeutics and oral biopharmaceutical delivery

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Mushrooms are emerging as natural medicine factories that can be genetically engineered to produce medications taken by mouth. Beyond their traditional use as health foods, scientists are now using advanced genetic techniques to program mushrooms to manufacture therapeutic proteins and vaccines. These engineered mushrooms can naturally package and protect these medications as they pass through the stomach, releasing them safely in the intestines for absorption. This approach offers a sustainable, affordable, and cold-chain-independent alternative to conventional injected medications.

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Advancing Pistacia terebinthus L. (Anacardiaceae) Research: Food Preservation, Functional Foods, and Nutraceutical Potential

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The turpentine tree (Pistacia terebinthus L.) is a Mediterranean plant traditionally used in food and medicine that is now being studied for modern food applications. Its fruits, seeds, leaves, and resin contain powerful compounds that fight bacteria, reduce oxidative stress, and promote health. Scientists are developing new techniques like microencapsulation and fermentation to preserve its beneficial properties in functional foods, yogurt, and other products. This underutilized plant could become an important natural ingredient for food preservation and health supplements.

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Genetic regulation of l-tryptophan metabolism in Psilocybe mexicana supports psilocybin biosynthesis

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Researchers studied how magic mushrooms (Psilocybe mexicana) regulate their chemistry to produce psilocybin, the psychoactive compound. They found that when mushrooms start fruiting, they turn on genes that make tryptophan (an amino acid building block) and turn off genes that break it down, directing all the tryptophan toward psilocybin production. This coordinated genetic control ensures the mushroom has enough of this key ingredient. This knowledge could help grow these mushrooms in labs for legitimate medical research into treating depression.

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Integration of Metabolomes and Transcriptomes Provides Insights into Morphogenesis and Maturation in Morchella sextelata

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Researchers studied how morel mushrooms develop from mycelium through fruiting body maturation by analyzing changes in their metabolites and genes across four growth stages. They found that the transition from vegetative growth to reproductive growth involves dramatic changes in carbohydrate, amino acid, and lipid metabolism, regulated by specific transcription factors. This understanding could help improve the cultivation of morels, which currently struggles with low fruiting rates despite their high value as food and medicine.

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