metabolic profiling – mycolab.ai

Effects and formula optimization of Rosa roxbunghii pomace substrate on the yield and volatile flavor compounds of Lentinula edodes

mycolabadmin

Researchers discovered that using Rosa roxbunghii fruit waste as 30% of the growing medium for shiitake mushrooms produces better yields and more flavorful mushrooms compared to traditional sawdust-based methods. This sustainable approach solves a waste disposal problem while making mushrooms taste better, with higher levels of umami-contributing compounds. The findings could help local farmers reduce costs and improve mushroom quality while managing agricultural waste responsibly.

Metabolic profiling of endophytic fungi acting as antagonists of the banana pathogen Colletotrichum musae

mycolabadmin

Scientists found three special fungi living inside rainforest plants in the Philippines that can fight the fungus causing banana rot. These endophytic fungi produce chemical compounds that stop the disease-causing fungus from growing, offering a natural alternative to traditional fungicides. The researchers found that the type of growing medium affects which compounds these fungi produce, and two promising strains could potentially be used to reduce fruit losses during storage and transport.

The Antioxidant Properties of Extracts of Cuscuta spp. Depend on the Parasite and the Host Species

mycolabadmin

Dodder plants (Cuscuta species) used in traditional medicine contain powerful antioxidant compounds that can help protect cells from damage. This study found that different dodder species have varying amounts of these beneficial compounds, and surprisingly, the type of host plant the dodder parasitizes directly affects how many antioxidants it produces. When dodders infect aromatic plants like thyme and rosemary, they accumulate more antioxidant compounds than when grown on other plants.

Insights into metabolic and pharmacological profiling of Aspergillus ficuum through bioinformatics and experimental techniques

mycolabadmin

Researchers studied a fungus called Aspergillus ficuum and found it contains compounds with potential medicinal benefits. The fungal extract showed strong antibacterial activity against disease-causing bacteria and reduced inflammation in mice. Additionally, the extract had antioxidant properties that help fight harmful free radicals, with no toxic effects observed, making it a promising candidate for developing new medications.

Gene fusion and functional diversification of P450 genes facilitate thermophilic fungal adaptation to temperature change

mycolabadmin

Researchers discovered that a thermophilic fungus uses two special genes to adapt to temperature changes. One of these genes is uniquely fused from two different genes, creating a hybrid protein with multiple functions. These genes help the fungus produce iron-binding molecules that stabilize its structure and support its growth when temperatures drop, allowing the fungus to survive in environments from compost piles to stored grains.

Screening of Basidiomycete Strains Capable of Synthesizing Antibacterial and Antifungal Metabolites

mycolabadmin

Researchers tested 18 types of medicinal mushrooms to see if they could produce natural antibiotics. Most of them (16 out of 18) showed antimicrobial properties, with some being particularly effective against dangerous bacteria and fungi. The most promising mushroom strain (Hericium corraloides 4) showed strong activity against multiple disease-causing organisms. This research suggests that mushrooms could be valuable sources for developing new antibiotics to fight drug-resistant infections.

Multiomics Provides a New Understanding of the Effect of Temperature Change on the Fermentation Quality of Ophiocordyceps sinensis

mycolabadmin

This research studied how temperature affects the growth and quality of Ophiocordyceps sinensis, a valuable medicinal fungus. Scientists found that the fungus grows best between 18-23°C, and that temperatures above 28°C damage the fungus by triggering cell death processes. The study identified which genes and metabolites are affected by temperature changes, helping optimize large-scale production of this medicinal fungus.

PTP1B deficiency in myeloid cells increases susceptibility to Candida albicans systemic infection by modulating antifungal immunity

mycolabadmin

This research shows that a protein called PTP1B plays an important role in protecting the body against dangerous fungal infections caused by Candida albicans. When mice lacked this protein in their immune cells, they were much more susceptible to the infection and showed severe illness. The study found that PTP1B helps immune cells like macrophages and neutrophils fight the fungus effectively, and blocking this protein could actually make fungal infections worse.

Screening of Basidiomycete Strains Capable of Synthesizing Antibacterial and Antifungal Metabolites

mycolabadmin

Researchers tested 18 different types of wood-decay fungi (basidiomycetes) to see if they could produce natural antibiotics and antifungal compounds. They found that 16 of the 18 strains successfully produced antimicrobial substances. Five strains were particularly promising, showing strong activity against dangerous bacteria including antibiotic-resistant strains. The study identified specific chemical compounds from these fungi that could potentially be developed into new medicines.

Carbon substrates utilization determine antagonistic fungal-fungal interactions among root-associated fungi

mycolabadmin

Scientists studied how different fungi in plant roots compete with disease-causing fungi. They found that fungi with different eating habits (carbon substrate preferences) fight off plant pathogens in different ways. Some fungi that eat many types of food produced toxic compounds to kill pathogens, while others competed directly for food. This discovery could help farmers use beneficial fungi to naturally protect crops from diseases.

Research Keyword: metabolic profiling