meta-analysis – mycolab.ai

Effects of classical psychedelics on implicit and explicit emotional empathy and cognitive empathy: a meta-analysis of MET task

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This study compiled data from multiple research studies to understand how classical psychedelics like LSD, psilocybin, and ayahuasca affect empathy—the ability to understand and share others’ feelings. The findings show these substances significantly increase emotional empathy, helping people feel more connected to others’ emotions. However, they don’t appear to affect cognitive empathy, which is the mental ability to understand what others are thinking. These results suggest psychedelics may have therapeutic potential for improving social connection and emotional understanding.

Trajectory of Antidepressant Effects after Single- or Two-Dose Administration of Psilocybin: A Systematic Review and Multivariate Meta-Analysis

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This comprehensive analysis of 10 clinical trials shows that psilocybin, a compound from magic mushrooms, can rapidly reduce depression symptoms starting within one day of administration and maintain these benefits for up to 6 months. Higher doses and two treatment sessions produced better results than single lower doses. While psilocybin did raise blood pressure temporarily, it was generally well-tolerated with dropout rates similar to placebo.

The effectiveness of interventions to reduce the transmission of acute respiratory infections in care homes: a systematic review

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This systematic review examined effective ways to prevent respiratory infections like flu and COVID-19 in care homes where elderly residents live. The researchers found that antiviral medications like oseltamivir can halve the risk of influenza even in vaccinated residents if given within 7 days of detecting a case. High-dose vitamin D supplementation (100,000 IU monthly) reduced respiratory infection risk by 40%. Educational programs to improve staff hygiene practices showed mixed results, while other supplements like probiotics did not significantly help.

The Role of Psychedelics in the Treatment of Substance Use Disorders: An Overview of Systematic Reviews

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This research review examines how psychedelic drugs like psilocybin and ketamine might help treat addiction. Studies show these substances could help people quit alcohol, drugs, and smoking by reducing cravings and promoting long-term abstinence. While results are promising, scientists caution that more rigorous research is needed before these treatments can be recommended for regular medical use, and they acknowledge real risks associated with these powerful drugs.

Rediscovering Psilocybin as an Antidepressive Treatment Strategy

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Scientists have renewed their investigation into psilocybin, a compound found in certain mushrooms, as a potential treatment for depression. Studies show promising results with patients experiencing significant improvements in depressive symptoms, sometimes sustained for months after a single treatment session. When administered in controlled therapeutic environments with professional support, psilocybin appears relatively safe, though it can cause temporary side effects like headaches and anxiety. This research represents an important shift in how we might treat severe depression, especially in patients who haven’t responded to conventional antidepressants.

Efficacy of prebiotic, probiotic and synbiotic administration in improving growth in children aged 0–59 months living in low- and middle-income countries: a systematic review and meta-analysis

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This comprehensive review examined whether giving children special dietary supplements containing beneficial bacteria and their food sources (prebiotics, probiotics, or synbiotics) helps them grow better in low-income countries. The analysis of eight studies found that these supplements may help children gain weight, especially those who are malnourished, though the evidence remains limited. More research is needed to fully understand whether these supplements are truly effective for promoting healthy growth in young children.

Efficacy of psilocybin for treating symptoms of depression: systematic review and meta-analysis

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This comprehensive analysis of clinical trials found that psilocybin, a compound found in certain mushrooms, shows promise as a treatment for depression compared to placebo. The treatment was particularly effective for patients with depression related to serious illness, those using self-reported symptom assessments, older adults, and those with prior experience with psychedelics. While side effects were minimal and temporary, researchers emphasize that more research is needed to fully understand how expectancy and individual factors influence treatment outcomes.

CORRECTION: Efficacy of psilocybin for treating symptoms of depression: systematic review and meta-analysis

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A major research study examining psilocybin’s effectiveness for treating depression has been corrected due to mathematical and data handling errors. The researchers fixed these issues by recalculating statistics and removing duplicate data from their analysis. While the main conclusions remained similar after correction, the authors emphasize this research is still preliminary and should lead to further study before clinical use.

Reconsidering evidence for psychedelic-induced psychosis: An overview of reviews, a systematic review, and meta-analysis of human studies

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This research review examined whether people with schizophrenia can safely participate in psychedelic-assisted therapy treatments. Researchers analyzed 131 studies and found that psychedelics rarely cause new psychosis in the general population (0.002%), though the risk is slightly higher in people with existing schizophrenia (3.8%). While the immediate risk appears manageable, about 13% of people who develop psychosis from psychedelics go on to develop schizophrenia, suggesting caution is still needed.

Risk factors for invasive fungal infections in adult patients with hematological malignancies and/or stem cell transplant: a systematic review and meta-analysis

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This comprehensive study analyzed multiple research papers to identify which patients with blood cancers or stem cell transplants are most likely to develop serious fungal infections. The researchers found that patients who previously had a stem cell transplant, those taking corticosteroids, and those with low white blood cell counts face the highest risks. Importantly, the study showed that using antifungal medications as a preventive treatment significantly reduces infection risk in these vulnerable patients.

Research Keyword: meta-analysis