memory formation – mycolab.ai

Postsynaptic plasticity of cholinergic synapses underlies the induction and expression of appetitive and familiarity memories in Drosophila

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Scientists discovered that fruit flies store memories using postsynaptic changes at cholinergic synapses, similar to how humans use postsynaptic mechanisms at glutamate synapses. Specific acetylcholine receptor subunits (α5 and α2) in brain cells called M4/6 neurons are required for different stages of memory formation. The research shows that fundamental memory storage mechanisms are conserved across evolution despite differences in the chemical messengers used.

Dopamine activity in projection neurons regulates short-lasting olfactory approach memory in Drosophila

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Fruit flies learn to avoid dangerous smells and approach safe smells during training. Scientists discovered that flies form both types of memories at the same time, but they work differently in the brain. Safe-smell memories are made using special brain areas and chemical signals that are different from danger memories. These findings help us understand how brains separate good and bad experiences.

Regulation of long-term memory by a few clock neurons in Drosophila

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Researchers discovered that just a few special nerve cells in fruit fly brains control how memories are formed and maintained. These clock neurons use a protein called Period to help convert short-term memories into long-term memories that can last for days. Understanding how these small groups of neurons regulate memory in flies could provide insights into how human brains form and maintain memories.

Research Keyword: memory formation

Postsynaptic plasticity of cholinergic synapses underlies the induction and expression of appetitive and familiarity memories in Drosophila

Dopamine activity in projection neurons regulates short-lasting olfactory approach memory in Drosophila

Regulation of long-term memory by a few clock neurons in Drosophila