Research Keyword: memory consolidation

Selective consolidation of learning and memory via recall-gated plasticity

Our brains use two memory systems working together: a quick short-term system and a slower long-term system. This study explains how the brain smartly decides which memories are worth storing long-term. The key is that memories get consolidated into long-term storage only when the short-term system can strongly recall them, which filters out unreliable or false memories. This recall-gated mechanism lets the brain remember important information better while ignoring noise and distractions.

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An antagonism between Spinophilin and Syd-1 operates upstream of memory-promoting presynaptic long-term plasticity

This research reveals how two brain proteins called Spinophilin and Syd-1 work against each other to control how synapses strengthen during memory formation. When flies learn something new, these proteins reorganize the structure of synaptic connections through managing thin filaments called actin, which allows more neurotransmitters to be released. The study shows that this mechanism is essential for remembering information after learning, but not for the initial learning itself.

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