Research Keyword: membrane permeability

Antifungal Activity of Selected Naphthoquinones and Their Synergistic Combination with Amphotericin B Against Cryptococcus neoformans H99

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Researchers tested five compounds called naphthoquinones for their ability to fight a dangerous fungal infection called cryptococcosis. They found that one compound called 2-MNQ works especially well when combined with the standard antifungal drug amphotericin B, making the treatment more effective. This discovery could lead to better treatments for people with weakened immune systems who are vulnerable to this infection.

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Antifungal activity and mechanism of novel peptide Glycine max antimicrobial peptide (GmAMP) against fluconazole-resistant Candida tropicalis

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Scientists developed a new antimicrobial peptide called GmAMP that can effectively kill drug-resistant fungal infections caused by Candida tropicalis, a pathogen resistant to common antifungal medications. The peptide works by damaging the fungal cell membrane and is safe for human use. In laboratory tests using insect larvae, the peptide successfully treated infections and reduced the fungal burden, suggesting it could become a new treatment option for patients with resistant fungal infections.

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Antifungal Activity of Selected Naphthoquinones and Their Synergistic Combination with Amphotericin B Against Cryptococcus neoformans H99

mycolabadmin

Scientists tested five synthetic compounds called naphthoquinones to see if they could fight a serious fungal infection called cryptococcosis. They found that one compound called 2-MNQ worked well against the fungus and was even more effective when combined with a standard antifungal drug (amphotericin B). The combination was strong enough to potentially allow lower doses of the existing drug, which could reduce side effects while improving treatment outcomes.

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