melanogenesis – mycolab.ai

Synergistic impact of arbutin and kaempferol-7-O-α-l-rhamnopyranoside from Nephelium lappaceum L. on whitening efficacy and stability of cosmetic formulations

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This research demonstrates that a natural compound from rambutan seeds works synergistically with arbutin to create more effective skin whitening products. The combination is 35 times more potent than arbutin alone at preventing melanin production in skin cells. The resulting cosmetic formulation maintains its effectiveness and stability for approximately 5.2 months, offering a safer natural alternative to conventional skin lightening agents that can cause irritation.

Development of dihydrooxyresveratrol-loaded nanostructured lipid carriers for safe and effective treatment of hyperpigmentation

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This research developed a new skin-brightening treatment using nanoparticles to deliver oxyresveratrol and its modified form (DHO) more effectively to the skin. The scientists improved the stability of these compounds by creating tiny lipid-based carriers that protect them from light damage and help them penetrate the skin barrier. Testing showed these formulations safely reduced melanin production without harming healthy skin cells, offering promise for cosmetic products to treat dark spots and hyperpigmentation.

Synthesis and biological assessment of novel 4H-chromene-3-carbonitrile derivatives as tyrosinase inhibitors

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Researchers developed new chemical compounds that can block tyrosinase, an enzyme responsible for producing excessive skin pigment that causes dark spots and discoloration. The most effective compound (6f) works better than kojic acid, a commonly used skin-lightening ingredient, and could lead to safer treatments for hyperpigmentation and related skin conditions. Computer simulations showed that one form of the compound fits better into the enzyme’s active site, making it more effective at preventing melanin production.

Nomilin from Yuzu Seed Has In Vitro Antioxidant Activity and Downregulates Melanogenesis in B16F10 Melanoma Cells through the PKA/CREB Signaling Pathway

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Scientists extracted a compound called nomilin from yuzu seeds and tested whether it could lighten skin by reducing melanin production. They found that nomilin works by blocking an enzyme called tyrosinase that makes melanin, and it reduces the activity of cell signaling pathways involved in skin darkening. The study shows nomilin could be used as a natural skin-whitening ingredient in cosmetics without the side effects of synthetic alternatives.

Hirsutanone Isolated from the Bark of Alnus japonica Attenuates Melanogenesis via Dual Inhibition of Tyrosinase Activity and Expression of Melanogenic Proteins

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Researchers found that hirsutanone, a natural compound from East Asian alder bark, can reduce skin pigmentation by blocking melanin production through two mechanisms: directly inhibiting the tyrosinase enzyme and suppressing the cellular signals that trigger melanin-producing genes. In laboratory tests with both mouse and human skin cells, hirsutanone proved more effective than a related compound called oregonin at reducing melanin without harming the cells. This discovery suggests hirsutanone could potentially be developed into a treatment for pigmentation problems like age spots and melasma.

Antioxidant Potential-Rich Betel Leaves (Piper betle L.) Exert Depigmenting Action by Triggering Autophagy and Downregulating MITF/Tyrosinase In Vitro and In Vivo

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This research shows that betel leaves, a traditional herb used in Asian cultures, can lighten skin pigmentation through multiple mechanisms. The extract works by reducing tyrosinase enzyme activity, activating cellular cleanup processes called autophagy, and boosting the body’s natural antioxidant defenses. In both laboratory cells and living mice exposed to UV radiation, betel leaves extract effectively reduced unwanted skin darkening, suggesting it could be developed into safe natural skin-whitening products.

Mechanistic Insights into Tyrosinase-Catalyzed Metabolism of Hydroquinone: Implications for the Etiology of Exogenous Ochronosis and Cytotoxicity to Melanocytes

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Hydroquinone is a common ingredient in skin-lightening products that works through enzyme-mediated chemical reactions. This research revealed how an enzyme called tyrosinase processes hydroquinone through different chemical pathways, ultimately producing melanin-like compounds. The study found that long-term hydroquinone use may cause a darkening side effect called exogenous ochronosis through continued enzyme activity, and identified a new chemical marker to track this process.

Eumelanin Detection in Melanized Focal Changes but Not in Red Focal Changes on Atlantic Salmon (Salmo salar) Fillets

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Farmed Atlantic salmon sometimes develop unsightly black and red spots that reduce market value. Researchers analyzed these discolored areas and found that the black spots contain a type of melanin pigment (eumelanin) produced by immune cells called melanomacrophages. The red spots contain different compounds formed from oxidized proteins rather than true melanin. Understanding the chemical differences between these two types of spots could help salmon farmers develop better prevention strategies.

Anti-Inflammation and Anti-Melanogenic Effects of Maca Root Extracts Fermented Using Lactobacillus Strains

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Researchers studied maca root, an Andes plant traditionally used for health benefits, by fermenting it with beneficial bacteria (Lactobacillus strains). They tested whether fermented maca could reduce skin inflammation and prevent excessive skin darkening. The fermented version worked significantly better than regular maca at both reducing inflammation markers and inhibiting melanin production in skin cells, suggesting it could be a valuable ingredient in cosmetic products designed to brighten skin and reduce irritation.

Identification of (Z)-2-benzylidene-dihydroimidazothiazolone derivatives as tyrosinase inhibitors: Anti-melanogenic effects and in silico studies

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Scientists developed new chemical compounds that can block tyrosinase, an enzyme that produces skin pigment (melanin). These new compounds, called DHIT derivatives, work much better than existing skin lightening agents like kojic acid and appear to be safer. The best compound tested was 100 times more effective at stopping melanin production than kojic acid in laboratory tests and showed no toxicity to cells.

Research Keyword: melanogenesis