Research Keyword: medicinal chemistry

Indole-Based Compounds as Potential Drug Candidates for SARS-CoV-2

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Scientists are searching for new treatments for COVID-19 by studying indole-containing compounds, which are found in many plants and can be made in laboratories. Some approved drugs with indole structures, like the antiviral drug Arbidol, have been repurposed to fight COVID-19. Researchers are also designing new indole compounds and using computer simulations to predict which ones might work best against the virus’s key proteins.

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Synthesis and bioactivity of psilocybin analogues containing a stable carbon–phosphorus bond

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Researchers created new chemical versions of psilocybin (the active compound in magic mushrooms) that cannot be broken down by the body’s natural enzymes in the same way. They tested these new compounds to see if they could help with depression and anxiety by targeting specific brain receptors. The best compound worked well on the intended brain receptors but importantly showed less activity on a heart-related receptor, potentially making it safer than natural psilocybin.

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Evaluation of the Indazole Analogs of 5-MeO-DMT and Related Tryptamines as Serotonin Receptor 2 Agonists

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Researchers synthesized new drug candidates based on psychedelic molecules like 5-MeO-DMT, replacing the indole core with indazole scaffolds to potentially improve drug properties. While the lead compound VU6067416 showed excellent potency for serotonin receptors and favorable pharmacokinetics, it also activated 5-HT2B receptors strongly, raising safety concerns about heart problems. The study highlights the challenge of developing selective serotonin drugs and emphasizes the need for rigorous safety testing of psychedelic-based therapeutics.

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