Research Keyword: mechanism of action

Antifungal Agents in the 21st Century: Advances, Challenges, and Future Perspectives

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This review examines how doctors treat serious fungal infections and the growing problem of fungi becoming resistant to medications. The authors discuss different antifungal drugs, how they work, and why some fungi are becoming harder to treat. They emphasize that controlling fungal resistance requires coordinated efforts across hospitals, farms, and communities, especially since some agricultural pesticides are creating resistant strains that spread to sick patients.

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The Biological Activity of Ganoderma lucidum on Neurodegenerative Diseases: The Interplay between Different Active Compounds and the Pathological Hallmarks

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Reishi mushroom, used in traditional Asian medicine for centuries, contains over 400 bioactive compounds that show promise in protecting the brain from degenerative diseases like Alzheimer’s and Parkinson’s. The mushroom’s components work through multiple pathways to reduce inflammation, fight oxidative stress, and protect neurons from damage. While laboratory and animal studies show encouraging results, human clinical trials are needed to confirm its effectiveness as a treatment.

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Exploring the health benefits of Ganoderma: antimicrobial properties and mechanisms of action

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Ganoderma is a medicinal mushroom that has been used in traditional medicine for thousands of years and shows promise as a natural antibiotic. The mushroom contains special compounds like polysaccharides and triterpenoids that can kill harmful bacteria and fungi by damaging their cell walls and boosting your immune system. Recent research shows it works against common infections like those caused by staph bacteria and E. coli, and may even help fight antibiotic-resistant germs.

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Staurosporine as an Antifungal Agent

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Staurosporine is a natural compound from soil bacteria that can kill fungal infections. While originally known for its anti-cancer properties, scientists have recently rediscovered its strong antifungal activity, especially against dangerous drug-resistant fungi. The challenge is that it also damages human cells, but researchers are developing improved versions and combination treatments to make it safer and more effective.

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Recent innovations and challenges in the treatment of fungal infections

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Fungal infections are becoming more common and harder to treat due to drug resistance, especially in people with weakened immune systems. Current antifungal medications are becoming less effective because fungi are adapting to resist them, and these drugs can cause serious side effects. Scientists are developing new treatment strategies using combinations of existing drugs, engineered biological approaches, and specially designed delivery systems to overcome resistance and improve patient outcomes.

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Cell Wall-Mediated Antifungal Activity of the Aqueous Extract of Hedera helix L. Leaves Against Diplodia corticola

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Scientists discovered that extract from ivy leaves can effectively kill a fungus called Diplodia corticola that damages cork oak trees. The extract works by damaging the fungus’s protective cell wall rather than interfering with its internal chemistry. This natural alternative to chemical fungicides could help protect cork production worldwide while being safer for human health and the environment.

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Saponins, the Unexplored Secondary Metabolites in Plant Defense: Opportunities in Integrated Pest Management

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Plants naturally produce compounds called saponins that protect them from insects, fungi, bacteria, parasitic worms, and viruses. This review explains how saponins work as natural pest managers and discusses how plants rich in saponins, such as licorice and soapbark trees, could be used to develop environmentally friendly crop protection products instead of synthetic pesticides.

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