Research Keyword: MBON

Postsynaptic plasticity of cholinergic synapses underlies the induction and expression of appetitive and familiarity memories in Drosophila

Scientists discovered that fruit flies store memories using postsynaptic changes at cholinergic synapses, similar to how humans use postsynaptic mechanisms at glutamate synapses. Specific acetylcholine receptor subunits (α5 and α2) in brain cells called M4/6 neurons are required for different stages of memory formation. The research shows that fundamental memory storage mechanisms are conserved across evolution despite differences in the chemical messengers used.

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The cellular architecture of memory modules in Drosophila supports stochastic input integration

Scientists created a detailed computer model of a memory-processing neuron in the fruit fly brain to understand how memories are stored and recalled. The study found that the neuron’s design allows it to store many different memories using random connections from input neurons, similar to how a brain might encode multiple learned experiences. This research reveals that memories can be efficiently stored without requiring precise positioning of individual neural connections, suggesting the brain uses flexibility and randomness as computational strategies.

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A dopamine-gated learning circuit underpins reproductive state-dependent odor preference in Drosophila females

Female fruit flies change their food preferences after mating, becoming attracted to nutrients important for egg production. This study reveals that during mating, pheromone detection triggers dopamine-driven changes in the fly’s brain learning center. These neural changes essentially ‘remember’ mating experience and reprogram the female’s sense of smell, even though the sensory neurons return to normal within hours. This demonstrates how an animal can learn from mating experience to make better nutritional choices as a mother.

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