mass spectrometry – mycolab.ai

Seaweed Protein Hydrolyzates: A Valuable Source of Short- and Medium-Chain Peptides with Multifunctional Properties

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Scientists found that an invasive seaweed species can be converted into health-promoting peptides (small protein fragments) that may help control blood pressure and blood sugar levels. The study identified hundreds of these peptides and tested their effectiveness against enzymes involved in hypertension and diabetes. The peptides showed promise as natural ingredients for functional foods designed to prevent metabolic diseases while also addressing the environmental problem of harmful seaweed blooms.

Olive mill solid waste induces beneficial mushroom-specialized metabolite diversity revealed by computational metabolomics strategies

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This study shows how adding olive mill waste to mushroom growing substrate can increase beneficial compounds in mushrooms while reducing harmful toxins. Researchers grew two types of edible mushrooms (lion’s mane and king oyster) on substrate containing different amounts of olive mill waste and used advanced chemical analysis to identify how the waste affected the mushrooms’ medicinal compounds. Adding olive mill waste increased healthy compounds like hericenones and erinacerins while decreasing toxic enniatin compounds, potentially creating safer and more nutritious mushrooms for consumers.

Decoding small peptides: Regulators of plant growth and stress resilience

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Small peptides are tiny protein-like molecules that act as chemical messengers in plants, controlling growth, development, and how plants respond to stress. Scientists have recently developed better tools to find and study these peptides, discovering they play important roles in helping plants adapt to harsh environments like drought and disease. These findings could help create crops that are more resilient and productive, addressing challenges posed by climate change and food security.

Therapeutic Potential of Bioactive Compounds in Edible Mushroom-Derived Extracellular Vesicles: Isolation and Characterization of EVs from Pleurotus eryngii

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Researchers isolated tiny particles called extracellular vesicles (EVs) from a medicinal mushroom called king oyster mushroom (Pleurotus eryngii). These EVs act like natural delivery packages containing beneficial compounds like antioxidants and anti-inflammatory molecules. The study found that EVs from mushroom mycelium (the root-like part) were purer and more potent than those from the mushroom cap, with strong abilities to neutralize harmful free radicals in the body.

Behavioral Phenotyping and Metabolomic Comparison of Chemically Synthesized Psilocybin and Psychedelic Mushroom Extract in a Zebrafish Depression Model

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Researchers compared chemically made psilocybin with whole mushroom extract in zebrafish to test for depression-like effects. Both treatments reversed depressive behaviors and produced similar changes in brain chemicals, though the mushroom extract showed more neurotransmitter precursors. This study demonstrates that zebrafish can be useful models for studying how psychedelics might help treat depression.

Deciphering the formation of biogenic nanoparticles and their protein corona: State-of-the-art and analytical challenges

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Scientists have developed environmentally friendly methods to create tiny metal particles (nanoparticles) using living organisms like bacteria, fungi, and plants instead of toxic chemicals. These bioengineered nanoparticles are coated with natural biological molecules that make them safer and more stable. This review explains how these particles are made, what analytical tools scientists use to study them, and their potential uses in medicine, environmental cleanup, and agriculture.

Fungal Metabolomics: A Comprehensive Approach to Understanding Pathogenesis in Humans and Identifying Potential Therapeutics

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This review explains how scientists use metabolomics—a technique that identifies all chemical compounds in organisms—to understand how fungi cause disease and resist medicines. Fungi produce many different chemicals that help them attack our bodies and survive treatments, but these same chemicals could also be used to create new medicines. By studying these fungal chemicals, researchers can develop better antifungal drugs and understand how fungi manage to evade our immune system.

Novel Antimicrobial Activities of Albofungin, Albonoursin, and Ribonucleosides Produced by Streptomyces sp. Caat 5-35 Against Phytopathogens and Their Potential as a Biocontrol Agent

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Scientists discovered that a soil bacterium called Streptomyces sp. Caat 5-35 produces natural compounds that can kill crop-damaging pathogens. These compounds, including albofungin and albonoursin, showed strong activity against diseases affecting cacao and palm crops. The bacterium also helps plants by breaking down cellulose and making phosphorus more available, making it a promising tool for natural crop protection without synthetic chemicals.

Molecular networking identifies an AHR-modulating benzothiazole from white button mushrooms (Agaricus bisporus)

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Researchers discovered a new compound in white button mushrooms called 2-amino-4-methylbenzothiazole that activates the aryl hydrocarbon receptor, which helps regulate gut health and immunity. Using a computational approach called molecular networking to compare mushroom compounds with known beneficial substances, scientists identified this previously unknown compound and confirmed its activity in laboratory cells. This discovery demonstrates how certain mushrooms may contribute to health through specific bioactive compounds and provides a faster method for finding similar compounds in other foods.

Screening and identifying natural products with SARS-CoV-2 infection inhibitory activity from medicinal fungi

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Researchers screened 167 extracts from 36 medicinal fungi to find natural compounds that could fight COVID-19. They discovered that certain fungi, particularly Inonotus obliquus and Pholiota adiposa, contain polysaccharides that effectively block the virus from infecting cells. These natural compounds showed promise as potential safe alternatives for developing new COVID-19 treatments and may have applications against other viral diseases.

Research Keyword: mass spectrometry