Macrophage polarization

Integration of active ingredients from traditional Chinese medicine with nano-delivery systems for tumor immunotherapy

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This review examines how traditional Chinese medicine ingredients can boost the body’s natural ability to fight cancer when combined with tiny nanoparticles that deliver drugs more effectively. The nanoparticles help TCM compounds work better by improving how they dissolve, how long they stay in the body, and where they target. By activating immune cells like natural killer cells and dendritic cells while reducing immune-suppressing cells, this combination approach offers a promising new strategy for cancer treatment with fewer side effects.

Regulatory effects of Lycium Barbarum polysaccharides on immune function and their application prospects

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Lycium barbarum, a plant used in traditional Chinese medicine for over 2000 years, contains special compounds called polysaccharides that boost the immune system. These compounds work by activating immune cells like macrophages and T cells, and can help fight infections and reduce inflammation. Research shows they may also help with conditions like arthritis, cancer, and gut health by acting as a natural prebiotic that promotes beneficial bacteria.

Tumor-associated macrophages in tumor progression and the role of traditional Chinese medicine in regulating TAMs to enhance antitumor effects

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This review explains how tumor-associated macrophages (immune cells) can either fight or help cancer depending on their type. Traditional Chinese Medicine contains compounds that can reprogram these macrophages to fight cancer more effectively. By shifting macrophages from a cancer-supporting state to a cancer-fighting state, TCM treatments could enhance the body’s natural ability to combat tumors and reduce side effects of conventional cancer therapies.

Anti-Inflammatory Effects of Solanum tuberosum L. Polysaccharide and Its Limited Gene Expression Profile

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Researchers studied a natural compound from potatoes called STP that reduces inflammation in the body. Using laboratory cells and animal models, they found that STP works similarly to the common pain reliever ibuprofen by reducing inflammatory chemicals and activating the body’s protective defense systems. This discovery suggests that potato-based polysaccharides could be developed into new treatments for inflammatory diseases and conditions related to oxidative stress.

Polyphenolic Hispolon Derived from Medicinal Mushrooms of the Inonotus and Phellinus Genera Promotes Wound Healing in Hyperglycemia-Induced Impairments

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Researchers tested a natural compound called hispolon, extracted from medicinal mushrooms, to see if it could help heal wounds in diabetic patients. Using both laboratory cells and diabetic rats, they found that hispolon successfully reduced cell damage caused by high blood sugar, improved wound closure, and promoted healthy tissue growth. The compound worked as well as an existing diabetic wound cream and showed no harmful side effects, suggesting it could become a new natural treatment option for diabetic wound complications.

Immunomodulatory activity of Pleurotus pulmonarius crude extract to human monocyte against Cryptococcus neoformans

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This research shows that an extract from the Phoenix oyster mushroom (Pleurotus pulmonarius) can boost the body’s immune cells to fight dangerous fungal infections caused by Cryptococcus neoformans. When immune cells are pre-exposed to this mushroom extract and then encounter the fungus, they become more effective at killing it through increased production of immune-signaling molecules and reactive oxygen species. This natural supplement approach offers a promising alternative to traditional antifungal drugs, which often have significant side effects and can lead to drug resistance.

Three Different Types of β-Glucans Enhance Cognition: The Role of the Gut-Brain Axis

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Researchers tested three types of β-glucans—fiber compounds found in mushrooms, oats, and other foods—to see if they could improve memory in mice. All three types enhanced recognition memory and reduced brain inflammation, while only oat β-glucan significantly changed gut bacteria composition. The findings suggest that different β-glucans may help prevent cognitive decline through different mechanisms involving the gut-brain connection.

Exploring the Anticancer Potential of Coriolus versicolor in Breast Cancer: A Review

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Coriolus versicolor, also known as turkey tail mushroom, has been used in traditional Chinese medicine for thousands of years. Recent scientific research shows it may help fight breast cancer through multiple mechanisms: killing cancer cells directly through programmed cell death pathways, breaking down the estrogen that fuels some breast cancers, preventing cancer spread, and boosting the immune system. While early studies are promising and one clinical trial showed good safety and immune benefits, larger studies are needed before this mushroom can be recommended as an official cancer treatment.

Research Keyword: Macrophage polarization