Research Keyword: macrophage phagocytosis

The dimorphic fungus Talaromyces marneffei: An opportunistic killer in Southeast Asia

Talaromyces marneffei is a dangerous fungus found in Southeast Asian soils that causes serious lung infections when people breathe in its spores. The fungus has a clever trick: it transforms into different forms depending on temperature and hides inside immune cells by tricking them. People with weak immune systems, particularly those with advanced HIV/AIDS or certain genetic conditions, are most vulnerable to severe disease.

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Condition-dependent effects of Elexacaftor/Tezacaftor/Ivacaftor (Trikafta) on Aspergillus fumigatus growth

Researchers studied how Trikafta, a new cystic fibrosis medication, affects Aspergillus fungus growth. While Trikafta doesn’t directly kill the fungus, it makes antifungal drugs more effective and improves patients’ lung function to help clear infections naturally. However, high concentrations of the drug may reduce the immune system’s ability to fight the fungus, suggesting careful monitoring of patients is needed.

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