Research Keyword: macrophage function

Condition-dependent effects of Elexacaftor/Tezacaftor/Ivacaftor (Trikafta) on Aspergillus fumigatus growth

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Researchers studied how Trikafta, a new cystic fibrosis medication, affects Aspergillus fungus growth. While Trikafta doesn’t directly kill the fungus, it makes antifungal drugs more effective and improves patients’ lung function to help clear infections naturally. However, high concentrations of the drug may reduce the immune system’s ability to fight the fungus, suggesting careful monitoring of patients is needed.

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Immunomodulatory functions of fungal melanins in respiratory infections

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Some dangerous fungi produce a dark pigment called melanin that acts like a cloak, protecting them from the body’s immune system. This review explains how melanin blocks multiple immune defenses, including suppressing warning signals to immune cells, preventing immune cells from engulfing and killing the fungi, and even absorbing harmful reactive molecules. Understanding these sneaky tactics could help scientists develop new treatments that strip away this protective cloak, making the fungi vulnerable to both the body’s natural defenses and antifungal drugs.

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PTP1B deficiency in myeloid cells increases susceptibility to Candida albicans systemic infection by modulating antifungal immunity

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This research shows that a protein called PTP1B plays an important role in protecting the body against dangerous yeast infections caused by Candida albicans. When this protein is missing from immune cells, mice become much more susceptible to severe fungal infections. The study found that PTP1B helps immune cells called macrophages and neutrophils kill fungi effectively, and when it’s absent, these immune cells work poorly. This discovery suggests that targeting PTP1B could be a new way to help patients fight off serious fungal infections.

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PTP1B deficiency in myeloid cells increases susceptibility to Candida albicans systemic infection by modulating antifungal immunity

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This research shows that a protein called PTP1B plays an important role in protecting the body against dangerous fungal infections caused by Candida albicans. When mice lacked this protein in their immune cells, they were much more susceptible to the infection and showed severe illness. The study found that PTP1B helps immune cells like macrophages and neutrophils fight the fungus effectively, and blocking this protein could actually make fungal infections worse.

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