A 41-year-old woman with Long-COVID experienced severe symptoms including fatigue, depression, anxiety, headaches, and brain fog that didn’t improve with traditional treatments. She decided to try psilocybin mushrooms and MDMA with guidance from a therapist. After multiple dosing sessions over several months, she reported roughly 80-90% improvement in her symptoms and was able to return to work and resume her studies. While this single case is promising, more research is needed to determine whether these psychedelics are truly safe and effective for Long-COVID.