Research Keyword: liver disease

Fermented Rice Bran: A Promising Therapeutic Agent Against High-Fat Diet-Induced Metabolic Disorders

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Fermented rice bran, created by fermenting rice byproduct with beneficial bacteria, shows promise in helping manage weight and blood sugar levels in studies using rats on high-fat diets. The fermentation process increases the nutritional value of rice bran by boosting protein, fiber, and antioxidant content. Animals supplemented with fermented rice bran for 8 weeks showed improved cognitive function, better liver health, and improved lipid profiles compared to those on high-fat diets alone.

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Targeting the AMP-activated protein kinase pathway: the active metabolites of botanical drugs represent potential strategies for treating metabolic-associated fatty liver disease

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Fatty liver disease is becoming increasingly common and current medications have side effects like dangerously low blood sugar. This review shows that natural plant-based compounds and traditional Chinese herbs can activate a key protein (AMPK) in the body that helps burn fat and regulate sugar levels. Over 30 different plant compounds from foods and herbs like ginger, curcumin, and ganoderma mushrooms have been shown to improve fatty liver disease by activating this protein through multiple beneficial mechanisms.

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Sea buckthorn bioactive metabolites and their pharmacological potential in digestive diseases

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Sea buckthorn is an ancient medicinal plant containing hundreds of bioactive compounds that show promise in treating digestive diseases like stomach ulcers, colitis, and liver problems. This comprehensive review of 85 scientific studies found that sea buckthorn’s active ingredients work through multiple mechanisms including reducing inflammation, fighting harmful bacteria, protecting the intestinal lining, and balancing gut bacteria. The research suggests sea buckthorn could become a valuable natural supplement for digestive health, though more clinical trials are needed to confirm optimal doses and long-term effectiveness in humans.

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Inonotus obliquus aqueous extract prevents histopathological alterations in liver induced by environmental toxicant Microcystin

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This research shows that Chaga mushroom extract can protect the liver from damage caused by microcystin, a toxic chemical produced by cyanobacteria in water. When mice were exposed to microcystin, their livers became damaged, but treating them with Chaga mushroom extract restored normal liver function and prevented cell death. The study suggests Chaga mushroom could be used as a natural supplement to prevent liver toxicity from environmental pollutants.

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Inonotus hispidus Protects against Hyperlipidemia by Inhibiting Oxidative Stress and Inflammation through Nrf2/NF-κB Signaling in High Fat Diet Fed Mice

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Inonotus hispidus is an edible mushroom that may help treat obesity and high cholesterol by reducing fat levels and inflammation in the body. In mice fed a high-fat diet, the mushroom improved cholesterol profiles, reduced liver damage, and promoted beneficial gut bacteria. The beneficial effects appear to work through activating the body’s natural antioxidant defenses and reducing inflammation-causing proteins.

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Critical review on chemical compositions and health-promoting effects of mushroom Agaricus blazei Murill

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Agaricus blazei Murill is an edible mushroom that contains many beneficial compounds including polysaccharides, vitamins, and minerals. Research shows it may help boost the immune system, reduce blood sugar levels, protect the liver, fight inflammation, and even have anti-cancer properties. While animal studies show promising results, more human clinical trials are needed to confirm its health benefits and establish proper dosing for therapeutic use.

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Mycotoxin contamination in Malawi: A systematic review of progress and trends in contamination, knowledge, attitude, and practices

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This review examines mycotoxin (toxic mold) contamination in Malawi and found that most people—farmers, traders, and health workers—don’t know about these dangerous substances or how to prevent them. Although groundnuts and maize are well-studied, other commonly eaten foods like dried fish and mushrooms have been largely ignored in research. Despite years of efforts to educate communities, awareness remains critically low at about 24.5%, and poverty often forces people to eat contaminated food because it’s cheaper.

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