Research Keyword: liquid chromatography mass spectrometry

Metabolomics Profiling of White Button, Crimini, Portabella, Lion’s Mane, Maitake, Oyster, and Shiitake Mushrooms Using Untargeted Metabolomics and Targeted Amino Acid Analysis

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Researchers analyzed seven popular mushroom varieties to understand their chemical makeup. They found over 10,000 different compounds across all mushrooms, with each variety having its own unique set of chemicals. Lion’s mane and oyster mushrooms were particularly rich in L-ergothioneine, a special amino acid thought to have antioxidant and anti-aging properties. The common white button, crimini, and portabella mushrooms had similar nutrient profiles, while specialty mushrooms had distinct chemical signatures.

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Toxicology and Analysis of Psychoactive Tryptamines

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Tryptamines are a growing class of psychoactive drugs that can cause hallucinations and other dramatic changes in perception. These substances, including compounds like DMT and psilocybin from magic mushrooms, work by affecting serotonin receptors in the brain. While some research explores their potential medical use for treating depression and anxiety, they also carry serious risks including dangerous changes in heart rate, body temperature, and mental state. Scientists have developed new laboratory methods to detect these drugs in blood and urine samples to help doctors diagnose and treat overdoses.

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Isavuconazole: Need for therapeutic drug monitoring and CYP polymorphism testing

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A patient with a serious fungal infection of the sinuses caused by Rhizopus arrhizus received the antifungal drug isavuconazole. However, blood tests showed the drug was building up to dangerously high levels in her body. Genetic testing revealed she had a mutation that made her body unable to break down the drug normally. The doctors had to give her much smaller and less frequent doses while carefully monitoring her drug levels to keep her safe.

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