LC/MS – mycolab.ai

Metabolomics Profiling of White Button, Crimini, Portabella, Lion’s Mane, Maitake, Oyster, and Shiitake Mushrooms Using Untargeted Metabolomics and Targeted Amino Acid Analysis

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Researchers analyzed seven popular mushroom varieties to understand their chemical makeup. They found over 10,000 different compounds across all mushrooms, with each variety having its own unique set of chemicals. Lion’s mane and oyster mushrooms were particularly rich in L-ergothioneine, a special amino acid thought to have antioxidant and anti-aging properties. The common white button, crimini, and portabella mushrooms had similar nutrient profiles, while specialty mushrooms had distinct chemical signatures.

Comparative Metabolite Profiling Between Cordyceps sinensis and Other Cordyceps by Untargeted UHPLC-MS/MS

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This research compares the chemical compounds found in authentic Cordyceps sinensis with four similar but different Cordyceps species to identify which ones are real. Using advanced laboratory techniques, scientists detected thousands of chemical differences between the species. They found that genuine C. sinensis contains higher levels of specific beneficial compounds like nucleosides and certain fatty acids. These findings help consumers and merchants distinguish authentic Cordyceps from counterfeit products and lower-quality substitutes.

Glycosylation and sugar variations in tyrosol yield promising prebiotic-like effects

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This study tested whether chemically modified versions of tyrosol, a natural compound found in olives and red wine, could boost beneficial gut bacteria better than the original form. Researchers gave mice three different versions: plain tyrosol, natural salidroside (tyrosol with glucose attached), and a lab-created version with galactose attached instead. The galactose version worked best, promoting the most beneficial bacteria like Bifidobacteria and reducing harmful bacteria, potentially offering health benefits similar to prebiotic supplements.

Miniaturized high-throughput conversion of fungal strain collections into chemically characterized extract libraries for antimicrobial discovery

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Scientists developed a fast, automated method called FLECS-96 to screen hundreds of fungal species for antimicrobial compounds in a small 96-well plate format. The method combines fungal culture, chemical extraction, and analysis to identify promising candidates against resistant bacteria like Staphylococcus aureus. The team successfully identified two bioactive compounds from the fungi tested. This innovation could significantly speed up the discovery of new antibiotics to combat antibiotic-resistant infections.

Unlocking Reishi’s secrets: nutritional and medicinal traits of Ganoderma lucidum isolated from tree bark in Egypt

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Reishi mushrooms (Ganoderma lucidum) from Egypt show promise as natural medicine. Researchers tested extracts and found they can fight bacteria, viruses, and cancer cells in laboratory tests. The mushrooms are rich in beneficial compounds like vitamins and antioxidants. While the extract was not as strong as conventional drugs, it showed good safety profiles and potential for development into new medicines.

Metabolic fingerprinting to elucidate the biodegradation of phosphonoacetic acid and its impact on Penicillium metabolism

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Scientists studied how three types of mold fungi break down and use a phosphorus-containing compound called phosphonoacetic acid. Using advanced chemical analysis, they identified unique metabolic patterns in each fungal strain depending on whether they were given regular phosphorus or the more challenging phosphonoacetic acid. These findings reveal how fungi adapt their internal chemistry to handle different phosphorus sources and could help identify which fungi are best at breaking down harmful phosphorus-containing chemicals in the environment.

Chemical Composition, Bioactive Compounds, and Antioxidant Activity of Two Wild Edible Mushrooms Armillaria mellea and Macrolepiota procera from Two Countries (Morocco and Portugal)

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This study compared two edible wild mushrooms (honey fungus and parasol mushroom) from Morocco and Portugal to understand their health benefits. Both mushrooms were found to be rich in compounds with antioxidant properties that help protect cells from damage. The research shows that where mushrooms grow—whether in Morocco or Portugal—affects their chemical makeup and healing potential, with Moroccan honey fungus showing particularly strong antioxidant power.

Application of ATR-FTIR and FT-NIR spectroscopy coupled with chemometrics for species identification and quality prediction of boletes

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Researchers developed a fast and non-destructive method to identify different types of edible boletes and assess their nutritional quality by analyzing their amino acid content. Using special spectroscopy techniques combined with computer analysis, they achieved perfect accuracy in identifying five bolete species and could predict the amino acid content that contributes to flavor and nutrition. This breakthrough provides consumers with better protection against accidentally purchasing toxic mushroom species that look similar to edible ones, while helping food producers quickly assess quality without lengthy lab testing.

LC/MS- and GC/MS-based metabolomic profiling to determine changes in flavor quality and bioactive components of Phlebopus portentosus under low-temperature storage

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This research examines what happens to black bolete mushrooms when stored in the refrigerator. Scientists used advanced chemical analysis to track how the mushroom’s flavor and nutritional compounds change over a two-week period. They discovered that an earthy smell compound called geosmin builds up during storage, which affects how the mushroom tastes. The findings suggest that cold storage alone is not ideal, and better preservation methods need to be developed.

Research Keyword: LC/MS