This study shows that enriching brine shrimp (Artemia) with beneficial bacteria and prebiotic fiber significantly improves growth and health in young catfish. The enriched shrimp were fed to catfish larvae for two weeks, resulting in better weight gain, faster growth rates, and more efficient feed conversion. The beneficial bacteria successfully colonized the fish’s gut and promoted a healthier microbiota, offering an environmentally friendly alternative to antibiotics in fish farming.