Detection of ERG11 gene mutation in coding and non-coding regions of clinical Candida glabrata (Nakaseomyces glabratus) isolates from Pakistan
mycolabadmin
Researchers in Pakistan identified genetic mutations in a dangerous fungus called Candida glabrata that makes it resistant to azole drugs, which are commonly used to treat fungal infections. They examined eight clinical samples and found novel mutations in the ERG11 gene, particularly in the promoter region of resistant strains. These findings suggest that the fungus may be developing new ways to survive azole treatment, which has important implications for patient treatment strategies.