Research Keyword: lactate metabolism

Glutamate-specific gene linked to human brain evolution enhances synaptic plasticity and cognitive processes

Scientists discovered that a human gene called GLUD2, which evolved as our brains expanded, makes synapses stronger and more plastic through a lactate-dependent process. When they added this gene to mice, the animals showed improved memory, better learning ability, and stronger brain connections. This research suggests that GLUD2 played a key role in the evolution of human intelligence by enhancing the brain’s ability to form new neural connections and adapt to new information.

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