Research Keyword: ketoconazole

Dermatophytosis in a Chilean fox: first case of Nannizzia gypsea in Lycalopex griseus and the need for a one health approach

A young wild Chilean fox was found with a skin infection caused by a fungus called Nannizzia gypsea, which lives in soil and can infect animals and humans. This is the first time this fungus has been documented in foxes anywhere. Doctors treated the fox with an antifungal cream and it recovered completely. The case highlights how increasing urbanization and contact between domestic pets, wild animals, and humans can spread fungal diseases, emphasizing the need for a coordinated public health approach.

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Dermatophytosis in a Chilean fox: first case of Nannizzia gypsea in Lycalopex griseus and the need for a one health approach

A wild South American grey fox found near Santiago, Chile was treated for a skin infection caused by a fungus called Nannizzia gypsea. This is the first time this particular fungus has been documented in foxes, raising concerns about how increasing contact between domestic animals, wildlife, and humans due to urbanization may spread fungal diseases. The fox was successfully treated with topical antifungal cream, and the fungus was found to be susceptible to all tested antifungal medications.

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The Effect of Topical Ketoconazole and Topical Miconazole Nitrate in Modulating the Skin Microbiome and Mycobiome of Patients With Tinea Pedis

This study examined how two common antifungal creams (ketoconazole and miconazole) affect the complex community of bacteria and fungi living on the skin of people with athlete’s foot. Both treatments effectively reduced the harmful fungus causing the infection and improved symptoms, with ketoconazole working slightly faster. However, the researchers found that while these treatments reduced the disease-causing fungus, the skin’s normal microbial community did not fully recover to a healthy state, particularly in the spaces between the toes.

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A case report of childhood onychomycosis caused by the rare yeast Kodamaea ohmeri

A 5-year-old girl in Vietnam developed a nail infection caused by a rare yeast called Kodamaea ohmeri, which typically affects adults with diabetes or weak immune systems. The infection, appearing as white discoloration on the nails, was successfully treated with a topical antifungal cream applied three times daily for one month. This is the first reported case of this rare yeast causing nail infection in a child in Vietnam, and it demonstrates that topical treatment can be effective for fungal nail infections in children whose nails are thinner than adults.

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Coexistence of Malassezia Species and Microsporum canis in the Lesions of Adult with Tinea Capitis

A 60-year-old woman developed unusual hair loss and scalp inflammation that looked like dandruff but was actually a fungal infection caused by multiple fungi working together. Doctors found three different fungi in her scalp samples: one dermatophyte and two Malassezia species. Lab experiments showed that the Malassezia fungi actually helped the main disease-causing fungus grow better, which explains why the condition looked different from typical cases. After three months of antifungal medication, her symptoms cleared and her hair grew back.

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Unraveling the Fungi–Cancer Connection

Fungi living in and around tumors play surprisingly important roles in cancer development and treatment response, yet they have been largely overlooked compared to bacteria. Different cancer types host specific fungal species that can promote tumor growth through immune suppression and toxin production. By better understanding and potentially targeting these tumor-associated fungi, researchers believe we could develop new combination treatments that enhance the effectiveness of existing cancer therapies.

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