Research Keyword: keratoplasty

Fungal keratitis complicating the diagnosis of Acanthamoeba keratitis

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A 42-year-old farmer presented with a severe eye infection that was initially misdiagnosed as a viral infection caused by herpes simplex virus. When antiviral treatment failed, doctors discovered the patient had a fungal infection caused by Fusarium. However, advanced testing revealed she actually had a dual infection with both the fungus and a microscopic parasite called Acanthamoeba. The patient required corneal transplant surgery and combination therapy with multiple medications to control the infection and preserve vision.

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Localized Versus Diffuse Corneal Invasion in Fungal Keratitis: Histological Insights from Candida albicans and Fusarium falciforme

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This study compared how two different fungi invade the cornea (clear part of the eye) by examining tissue samples from patients who had severe eye infections. Candida stayed in one small area while Fusarium spread throughout the entire cornea tissue. The findings suggest that different fungi behave very differently when infecting the eye, which could help doctors choose better treatments. Understanding these differences may explain why Fusarium infections are much harder to treat with medications alone.

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Localized Versus Diffuse Corneal Invasion in Fungal Keratitis: Histological Insights from Candida albicans and Fusarium falciforme

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This study compared how two types of fungi invade the cornea of the eye. Candida albicans, a yeast, stayed localized to where it entered the eye and was easier to control surgically. In contrast, Fusarium falciforme, a mold, spread aggressively throughout the entire cornea and was much harder to treat. Understanding these different invasion patterns helps explain why some fungal eye infections are more difficult to manage than others.

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