Research Keyword: keratitis

Population structure in a fungal human pathogen is potentially linked to pathogenicity

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Aspergillus flavus is a common fungal infection found in both hospitals and the environment. Researchers studied the genetic makeup of 300 fungal samples from patients and the environment across multiple countries. They discovered that clinical isolates cluster into specific genetic groups, with one group containing most patient-derived samples. This finding suggests that certain genetic populations of this fungus may be better adapted to infecting humans than others.

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A 3D Fusarium keratitis model reveals isolate-specific adhesion and invasion properties in the Fusarium solani species complex

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Researchers studied three species of Fusarium fungus that cause serious eye infections. They found that one species (F. keratoplasticum) is much more dangerous than the others, invading deeper into the eye and causing more damage. Using a new 3D model that mimics the structure of the human cornea, they discovered that Fusarium fungi penetrate much deeper than other fungal pathogens, which helps explain why eye infections from these fungi are so difficult to treat and why patients often lose their vision.

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Population structure in a fungal human pathogen is potentially linked to pathogenicity

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A. flavus is a common fungal pathogen that causes serious infections in humans and damages crops. Researchers analyzed DNA from hundreds of fungal samples collected from both infected patients and environmental sources. They found that clinical isolates cluster into specific genetic groups, especially a newly identified group called population D that contains most of the disease-causing strains. This suggests that certain genetic variations make some fungal strains more likely to infect humans than others.

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Localized Versus Diffuse Corneal Invasion in Fungal Keratitis: Histological Insights from Candida albicans and Fusarium falciforme

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This study compared how two different fungi invade the cornea (clear part of the eye) by examining tissue samples from patients who had severe eye infections. Candida stayed in one small area while Fusarium spread throughout the entire cornea tissue. The findings suggest that different fungi behave very differently when infecting the eye, which could help doctors choose better treatments. Understanding these differences may explain why Fusarium infections are much harder to treat with medications alone.

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A case of corneal infection with Clonostachys rosea

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A 53-year-old patient developed a serious eye infection caused by a fungus called Clonostachys rosea, which had never been reported before as causing eye disease. The infection caused a painful ulcer on the cornea (the clear front part of the eye). Doctors treated the infection with antifungal medications applied as eye drops and taken as tablets, and the patient recovered well within about a month.

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Favorable outcome of Lasiodiplodia theobromae keratomycosis: a clinical case and systematic review

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A 74-year-old farmer developed a serious fungal eye infection caused by Lasiodiplodia theobromae, a rare tropical fungus. Instead of requiring eye surgery, the patient was successfully treated with a combination of two antifungal medications applied as eye drops and taken orally for eight weeks. This case is significant because it’s the first documented successful medical treatment of this particular fungal infection, highlighting the importance of quick diagnosis and avoiding corticosteroid eye drops that can worsen fungal infections.

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