Research Keyword: KEGG pathway enrichment

Transcriptome Analysis Reveals Mechanisms of Stripe Rust Response in Wheat Cultivar Anmai1350

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Researchers studied how a wheat variety called Anmai1350 defends itself against a fungal disease called stripe rust caused by Puccinia striiformis. By analyzing gene activity at different time points after infection, they discovered that the wheat plant’s immune system activates multiple defense strategies, including producing toxic molecules called reactive oxygen species and defensive compounds called phytoalexins that prevent the fungus from spreading. This research helps scientists understand how to breed wheat varieties that can naturally resist this damaging disease and maintain crop yields.

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Synergistic target network construction and dynamic simulation analysis based on a prospective systems pharmacology strategy

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Researchers used computer-based methods to study how Sang Huang, a traditional medicinal fungus, might help treat type 2 diabetes. They identified 17 active compounds in the fungus and found that a key component called estradiol dipropionate could improve insulin sensitivity and glucose control by activating specific protein pathways. The study suggests Sang Huang could be a promising natural treatment for diabetes, though more laboratory and animal testing is needed.

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Integrated transcriptome and metabolome profiling reveals mechanisms underlying the infection of Cytospora mali in “Jin Hong” branches

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This research examined how apple trees defend themselves against a serious fungal disease called Valsa canker caused by Cytospora mali. Scientists used advanced genetic and chemical analysis techniques to identify which genes and protective compounds are activated when apple branches are infected. They found that healthy apple trees fight the infection by strengthening their cell walls, producing special protective enzymes, and accumulating defense chemicals like α-linolenic acid and betaine. These discoveries could help develop better ways to prevent or manage this destructive disease in apple orchards.

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Transcriptomic and metabolic profiling reveals adaptive mechanisms of Auricularia heimuer to temperature stress

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Researchers studied how a popular edible mushroom called black wood ear (Auricularia heimuer) adapts to different temperatures. They found that the mushroom grows best at 35°C but struggles at very cold (15°C) or extremely hot (45°C) temperatures. By analyzing the genes and chemicals produced by the mushroom at different temperatures, scientists discovered that the mushroom uses different survival strategies depending on how hot or cold it is, which could help farmers grow better mushrooms.

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Integrated multi-omics identifies plant hormone signal transduction and phenylpropanoid biosynthesis as key pathways in kiwifruit (Actinidia chinensis var. deliciosa) resistance to Botryosphaeria Dothidea infection

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Kiwifruit can be infected by a fungus called Botryosphaeria dothidea, which causes soft rot and makes the fruit inedible. Researchers used advanced techniques to study what happens inside the fruit when infected, finding that certain plant hormones and chemical pathways become active to fight the infection. They identified two key genes that appear to control how the fruit responds to the fungus, which could help develop better ways to prevent this costly disease.

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Comparative Multi-Omics Analysis and Antitumor Activity of Phylloporia crataegi and Phylloporia fontanesiae

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Two species of medicinal fungi were studied to understand why one was better at fighting cancer cells. Researchers analyzed the chemicals, genes, and proteins in both fungi and found that Phylloporia crataegi had much higher levels of cancer-fighting compounds and activated special cellular defense pathways that harm cancer cells. This research shows that medicinal fungi could be promising sources for developing new cancer treatments.

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