itraconazole – Page 2

RttA, a Zn2-Cys6 transcription factor in Aspergillus fumigatus, contributes to azole resistance

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Researchers discovered that a protein called RttA helps a common fungus called Aspergillus fumigatus resist azole medicines, which are used to treat serious fungal infections. By studying how this protein works and which genes it controls, scientists found that RttA could be a new target for developing better antifungal treatments. The findings are important because azole-resistant fungal infections are becoming more common worldwide and harder to treat.

Randomized control trial to study the effectiveness of tablet Fluconazole, capsule Itraconazole and tablet Terbinafine in superficial dermatophytosis

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This study tested three common antifungal medications used to treat fungal skin infections like ringworm. The research involved 180 patients who were randomly given one of three drugs and then checked at 4 and 8 weeks to see if the infection was gone. Itraconazole worked best, clearing infections in about 87% of patients, followed by Fluconazole at 73%, and Terbinafine at 63%.

Basidiobolomycosis caused by a rare species – Basidiobolus meristosporus

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A five-year-old girl developed large swollen lumps on her buttock and thigh that were initially thought to be tuberculosis or cancer. Doctors took a tissue sample and found it was caused by a rare fungus called Basidiobolus meristosporus. Using advanced DNA sequencing techniques, they identified the exact fungus species and treated her successfully with an antifungal medication called itraconazole, leading to complete healing within six weeks.

Tinea genitalis profunda caused by Microsporum canis: A case report and literature review

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A 23-year-old woman developed a severe fungal infection in her genital area caused by a fungus typically found in dogs. The infection initially appeared bacterial and did not respond to antibiotics. Fungal cultures identified Microsporum canis, which was successfully treated with oral antifungal medications, though the patient experienced some scarring and pigmentation changes.

A case of refractory onychomycosis caused by Kloeckera apiculata: Successful treatment with itraconazole

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A 32-year-old man had a stubborn fungal nail infection caused by an extremely rare yeast called Kloeckera apiculata that didn’t respond to three different antifungal treatments over several years. After being identified through specialized laboratory testing including genetic sequencing, the infection was successfully cured with a 3-month course of the oral antifungal medication itraconazole. This case is notable because it is only the fourth known case of this rare fungal infection in humans and the first one to achieve complete cure with itraconazole treatment.

Deep cutaneous fungal infection in an immunocompetent individual caused by a biological pesticide: a rare case report

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A 66-year-old farmer developed recurring skin infections over 10 years from exposure to a biological pesticide containing a fungus called Purpureocillium lilacinum. Although this fungus is generally safe for healthy people, this case shows it can cause serious skin infections with prolonged exposure. The patient was successfully treated with antifungal medication over three months. This case highlights the importance of proper safety measures when working with biological pesticides.

Disseminated subcutaneous sporotrichosis in an immunocompetent patient: A case report and a systematic literature review

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A 74-year-old man developed painful red masses on his arm and hand after being stuck by a tree branch. Tests identified the infection was caused by a fungus called Sporothrix schenckii. Despite having a normal immune system, the infection had spread across his arm in an unusual pattern. Treatment with an antifungal medication called itraconazole completely healed the lesions within four months without any scarring.

Coexistence of Malassezia Species and Microsporum canis in the Lesions of Adult with Tinea Capitis

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A 60-year-old woman developed unusual hair loss and scalp inflammation that looked like dandruff but was actually a fungal infection caused by multiple fungi working together. Doctors found three different fungi in her scalp samples: one dermatophyte and two Malassezia species. Lab experiments showed that the Malassezia fungi actually helped the main disease-causing fungus grow better, which explains why the condition looked different from typical cases. After three months of antifungal medication, her symptoms cleared and her hair grew back.

Unraveling the Fungi–Cancer Connection

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Fungi living in and around tumors play surprisingly important roles in cancer development and treatment response, yet they have been largely overlooked compared to bacteria. Different cancer types host specific fungal species that can promote tumor growth through immune suppression and toxin production. By better understanding and potentially targeting these tumor-associated fungi, researchers believe we could develop new combination treatments that enhance the effectiveness of existing cancer therapies.

A case of Blastomyces helicus pneumonia in a dog from a non-endemic region: diagnostic challenges and successful treatment outcome

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A dog developed severe pneumonia from an emerging fungal infection called Blastomyces helicus after traveling to Utah and Idaho. Initial blood tests incorrectly suggested a different fungus, but laboratory culture and genetic testing identified the true culprit. The dog was successfully treated with an antifungal medication called itraconazole and made a complete recovery with careful monitoring over 6 months.

Research Keyword: itraconazole