itraconazole – mycolab.ai

A case report of disseminated histoplasmosis not responding to primary treatment by itraconazole

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A 28-year-old woman developed a fungal infection called histoplasmosis after having a tooth extracted, with the infection spreading to her lungs and sinuses. She was initially given a common antifungal medication called itraconazole, but her condition continued to worsen despite increasing the dose. When doctors switched her to a stronger medication called liposomal amphotericin B given intravenously, she improved dramatically and recovered fully. This case shows the importance of recognizing when a standard fungal treatment is not working and switching to more aggressive therapy.

Naganishia albidus Causing Perioral Cutaneous Infection: A Rare Case Easily Misdiagnosed

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A 37-year-old man developed an unusual fungal skin infection around his mouth caused by Naganishia albidus, a rare yeast. He was initially misdiagnosed with eczema and his condition worsened with wrong treatment. Advanced fungal testing techniques helped identify the correct organism, and after six weeks of antifungal medication (both oral and topical), his skin completely cleared. This case shows why doctors need to consider rare fungal infections when skin problems don’t respond to typical treatments.

Overexpression of efflux pump and biofilm associated genes in itraconazole resistant Candida albicans isolates causing onychomycosis

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This research examines why some fungal infections of the nails resist treatment with the antifungal drug itraconazole. Scientists found that resistant fungi produce more proteins that pump the drug out of their cells (efflux pumps) and form protective biofilm structures. Understanding these resistance mechanisms could help develop better combination treatments that work alongside antifungal drugs to overcome resistance.

Disseminated subcutaneous sporotrichosis in an immunocompetent patient: A case report and a systematic literature review

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A 74-year-old man developed multiple infected lumps on his arm, wrist, and finger months after being injured by a tree branch. Doctors identified the infection as sporotrichosis caused by a fungus called Sporothrix schenckii using advanced genetic testing. He was successfully treated with itraconazole tablets for several months and completely recovered. This case is unusual because sporotrichosis typically affects people with weakened immune systems, but this patient had a normal immune system.

Overexpression of efflux pump and biofilm associated genes in itraconazole resistant Candida albicans isolates causing onychomycosis

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Nail fungal infections caused by Candida albicans can be difficult to treat when the fungus becomes resistant to common antifungal medications like itraconazole. Researchers found that resistant strains have overactive genes that pump the drug out of fungal cells and genes that help the fungus form protective biofilm structures. Understanding these resistance mechanisms could lead to better combination treatments that block these protective strategies.

Madurella tropicana and Madurella pseudomycetomatis identified as new causative agents of black grain eumycetoma in Senegal

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This case report describes two patients in Senegal with a serious fungal infection called eumycetoma caused by previously unidentified fungal species. Using modern DNA sequencing methods, researchers identified the infections as being caused by Madurella tropicana and Madurella pseudomycetomatis, rather than the previously known Madurella mycetomatis. One patient treated with the antifungal drug itraconazole showed good improvement, highlighting the importance of accurate identification for proper treatment.

The impact of osteoarticular invasion by Coccidioides Sp disseminated infection

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A 48-year-old man from Mexico developed a serious fungal infection caused by Coccidioides, which spread from his lungs to his skin, bones, and joints, causing pain and swelling. Despite having a normally functioning immune system, he developed progressive disease that was initially misdiagnosed as rheumatoid arthritis. After switching to the antifungal medication fluconazole, his condition improved dramatically, with symptoms resolving within several months of treatment.

A case of Blastomyces helicus pneumonia in a dog from a non-endemic region: diagnostic challenges and successful treatment outcome

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A dog from Colorado developed a severe respiratory infection that was initially mistaken for a bacterial pneumonia. After antibiotics failed to help, advanced testing revealed the dog had a fungal infection caused by Blastomyces helicus, a rare fungus found in western North America. The dog was successfully treated with an antifungal medication called itraconazole and made a complete recovery within six months, demonstrating the importance of considering fungal infections when standard treatments fail.

Spread of Antifungal-Resistant Trichophyton indotineae, United Kingdom, 2017–2024

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A fungal infection called Trichophyton indotineae, which originated in Asia, is rapidly spreading throughout the United Kingdom and becoming resistant to common antifungal treatments. The infection typically starts in the groin area and can spread to other parts of the body, and many cases fail to respond to standard antifungal drugs like terbinafine. Researchers tracked 157 cases over seven years and found the fungus now accounts for over a third of all dermatophyte infections sent to the UK reference laboratory. Doctors and laboratory professionals are being urged to recognize this emerging threat and consider better diagnostic and treatment strategies.

Deep cutaneous fungal infection in an immunocompetent individual caused by a biological pesticide: a rare case report

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A 66-year-old farmer developed a deep skin fungal infection from a biological pesticide she used for over 10 years. The pesticide contained a fungus called Purpureocillium lilacinum, which is normally harmless to healthy people but caused repeated skin lesions on her face and arms. She was successfully treated with antifungal medication (itraconazole) for three months, and her skin fully healed without returning. This is the first reported case showing that biological pesticides can pose health risks to workers who handle them regularly.

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