Research Keyword: invasive fungal infection

Moving beyond multi-triazole to multi-fungicide resistance: Broader selection of drug resistance in the human fungal pathogen Aspergillus fumigatus

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Aspergillus fumigatus is a dangerous fungal infection treated with triazole drugs, but the fungus is developing resistance to multiple antifungal medications. This resistance appears to be selected in agricultural settings where fungicides are used on crops, and resistant strains then spread to humans through the air. The problem is worse because agricultural fungicides are selecting for strains resistant to multiple drug classes at once, making infections harder to treat. Addressing this issue requires reducing fungicide use in agriculture and better strategies for managing antifungal resistance.

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Breaking the mould: challenging the status quo of clinical trial response definitions for invasive fungal diseases—a debate

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Doctors and researchers use standard definitions to determine if antifungal treatments work in clinical trials. This debate examines whether the standards created in 2008 are still appropriate today. Key concerns include whether stable disease should always count as treatment failure, how to handle deaths from other causes, and whether newer testing methods should be incorporated. The expert panel concluded these definitions need updating to reflect modern treatment options and patient needs.

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Epidemiology of mucormycosis in COVID-19 patients in northwest Iran: Rhizopus arrhizus as the predominant species

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This study found that COVID-19 patients in northwestern Iran who received high-dose steroid treatment developed serious fungal infections called mucormycosis. The infection was caused primarily by a fungus called Rhizopus arrhizus and affected mainly the sinuses and brain. The steroids used to treat COVID-19 weakened patients’ immune systems and triggered diabetes, both of which made them vulnerable to this dangerous fungal infection.

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The tell-tale hearts: Donor-derived invasive fungal infections among orthotopic heart transplant recipients

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This case report describes two rare instances where fungal infections were transmitted from organ donors to heart transplant recipients. One involved a Candida infection and the other involved Aspergillus fungus, both causing serious bloodstream and heart infections. The patients required extensive antifungal medications and multiple surgeries to survive their infections, though they experienced significant complications. These cases highlight the importance of careful screening of organ donors for undetected infections.

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The Brief Case: Cutaneous ulceration associated with acalabrutinib treatment

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A 72-year-old patient being treated with acalabrutinib for blood cancer developed a slowly growing skin ulcer on the thigh. Testing identified a fungal infection caused by Alternaria alternata, a mold found in soil and air. The patient was successfully treated with an antifungal medication called posaconazole, with the ulcer healing over one month. This case highlights that doctors should check for fungal infections in chronic skin wounds of patients taking BTK inhibitor medications.

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Invasive Cutaneous Mucormycosis in a Patient With Chronic Lymphocytic Leukemia on Obinutuzumab, Idelalisib, and Bruton Tyrosine Kinase Degrader: A Case Report

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A 74-year-old man with leukemia developed a serious fungal infection (mucormycosis) on his ankle while taking cancer-fighting drugs. The infection was diagnosed through tissue biopsy examination rather than standard culture tests. Treatment required both powerful antifungal medications and surgical removal of the infected leg below the knee. The patient recovered successfully after this aggressive treatment approach.

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