invasive fungal infection – Page 4

Pulmonary Mucormycosis in Diabetic Patients: A Case Series From a Tertiary Respiratory Center in Sri Lanka

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This case study describes three patients with diabetes who developed a serious lung infection caused by a rare fungus called mucormycosis. The infection presented with various symptoms like cough, fever, and weight loss, and was diagnosed using lung tissue samples that showed the characteristic fungal structures. Two patients recovered with prolonged antifungal medication treatment, while one patient unfortunately died despite receiving prompt treatment, highlighting how serious this infection can be.

Invasive nasal and paranasal mucormycosis in a patient with severe dengue fever and multiple risk factors: A case report and literature review

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A 50-year-old woman in Vietnam developed a rare and deadly fungal infection called mucormycosis while recovering from dengue fever. She had weakened immunity from taking steroids for other conditions and from the dengue virus itself. The infection caused black, dead tissue to rapidly spread in her nose and around her eye. Despite treatment with antifungal medications, the infection progressed, and she died within days. The case shows how important it is to watch for dangerous opportunistic infections in dengue patients, especially those already dealing with weakened immune systems.

Masquerading Yeast: A Case Report of Lomentospora prolificans Fungemia With a Diagnostic Twist

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This case describes a patient with blood cancer who developed a rare and deadly mold infection called Lomentospora prolificans while receiving cancer treatment. The infection was difficult to diagnose initially because the fungal structures looked similar to yeast under the microscope, and a molecular test gave a false positive result for a different fungus. Unfortunately, the infection was resistant to all available antifungal medications and the patient died.

The In vitro Effect of Nanoliposomal Amphotericin B Against Rhizopus arrhizus Isolated From COVID-19-Associated Mucormycosis Patients

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Scientists tested a new nano-formulation of the antifungal drug amphotericin B against a dangerous fungus (Rhizopus arrhizus) that infected COVID-19 patients with mucormycosis. The nanoliposomal version of the drug worked much better than regular amphotericin B and other antifungal medications currently used, showing much lower concentrations needed to kill the fungus. This research suggests the new nano-formulation could be a more effective treatment option for patients with this serious COVID-19 related fungal infection.

Azole Resistance in Aspergillus Species Isolated from Clinical Samples: A Nine-Year Single-Center Study in Turkey (2015–2023)

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This study examined azole antifungal resistance in fungal infections from a Turkish hospital over nine years. Researchers tested 200 Aspergillus fungal isolates and found that 7% showed resistance to azole medications, with 11% of Aspergillus fumigatus showing resistance. The findings highlight the ongoing challenge of drug-resistant fungal infections and the importance of monitoring resistance patterns to improve treatment decisions for serious fungal infections.

Detection of Multiple Nosocomial Trichosporon asahii Transmission Events via Microsatellite Typing Assay, South America

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Researchers developed a genetic fingerprinting tool called microsatellite typing to track and identify outbreaks of a dangerous fungus called Trichosporon asahii in hospitals. This fungus causes life-threatening infections, especially in sick patients with weakened immune systems, and is resistant to many antifungal medications. By analyzing samples from hospitals across South America, scientists discovered multiple instances where the same strain of this fungus infected patients in different hospitals over many years. This new testing method is much cheaper and faster than other genetic tests, making it practical for hospitals worldwide to monitor and control infections caused by this emerging pathogen.

Detection of Mucorales antigen in bronchoalveolar lavage samples using a newly developed lateral-flow device

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Researchers tested a new rapid test device that detects a specific protein released by dangerous mold infections (mucormycosis) in patient respiratory samples. The test uses a special antibody to identify these molds quickly, which is important because mucormycosis can be life-threatening and requires fast treatment. The device showed promise with about 77% accuracy in identifying infections, though larger studies are needed to confirm these findings.

Inappropriate treatment of pulmonary aspergillosis caused by Aspergillus flavus in susceptible pediatric patients: a case series

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This case series describes three children in Iran who developed serious lung infections caused by a fungal organism called Aspergillus flavus. Tragically, two of the three children died because their infections were diagnosed too late and they did not receive appropriate antifungal medications. The study emphasizes that children with weakened immune systems need quick diagnosis and proper antifungal treatment to survive these dangerous fungal infections.

Shared Vision for Improving Outcomes for Serious Fungal Diseases: Report of a Patient, Caregiver, and Clinician Summit

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Patients with serious fungal infections face significant challenges including long delays before diagnosis, substantial emotional and financial burden, and lasting effects on quality of life. A summit brought together patients, their caregivers, and fungal disease experts to share experiences and identify priorities for improving care. The group identified needs for better diagnostic tools, new treatments, improved medical education about fungal diseases, and patient support programs to help future patients and their families navigate fungal infections more effectively.

First case of invasive Rasamsonia argillacea in a child with chronic granulomatous disease in Qatar

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A 16-year-old girl with a rare immune system disorder called chronic granulomatous disease developed a serious fungal infection caused by Rasamsonia argillacea, a fungus that is not commonly seen in clinical practice. The infection presented as a painful collection in her chest wall that required surgery and multiple antifungal medications. This is the first reported case of this particular fungal infection in the Arabian Peninsula, and successful treatment required a combination of drugs chosen based on laboratory testing of the fungus’s resistance patterns.

Research Keyword: invasive fungal infection