Research Keyword: intraspecific diversity

Detection of Multiple Nosocomial Trichosporon asahii Transmission Events via Microsatellite Typing Assay, South America

Researchers developed a genetic fingerprinting tool called microsatellite typing to track and identify outbreaks of a dangerous fungus called Trichosporon asahii in hospitals. This fungus causes life-threatening infections, especially in sick patients with weakened immune systems, and is resistant to many antifungal medications. By analyzing samples from hospitals across South America, scientists discovered multiple instances where the same strain of this fungus infected patients in different hospitals over many years. This new testing method is much cheaper and faster than other genetic tests, making it practical for hospitals worldwide to monitor and control infections caused by this emerging pathogen.

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mSphere of Influence: Population-level thinking to unravel microbial pathogenicity

This article discusses how scientists have traditionally divided fungi into clear categories of disease-causing pathogens versus harmless non-pathogens, often based on studying just one strain. Recent research shows that non-pathogenic fungi can actually have many disease-causing traits similar to pathogenic species, suggesting the boundary between dangerous and safe fungi is not as clear-cut as previously thought. By studying many different strains across species, researchers can better understand how fungal diseases develop and potentially evolve.

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