Research Keyword: intestinal permeability

Microbiota-based interventions for autism spectrum disorder: a systematic review of efficacy and clinical potential

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This comprehensive review examines how modifications to gut bacteria through probiotics, prebiotics, synbiotics, and fecal transplants can help children with autism. The research found that while all these treatments showed some promise, fecal microbiota transplantation (FMT) produced the most consistent improvements in both autism-related behaviors and digestive symptoms. These microbiota-based approaches work through the gut-brain connection and were generally safe, making them potentially valuable additions to autism management strategies.

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The Effect of 2′-Fucosyllactose on Gut Health in Aged Mice

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This research shows that 2′-fucosyllactose, a natural compound found in breast milk, can significantly improve gut health in older mice. The treatment strengthened the intestinal barrier, reduced harmful inflammation, and increased beneficial bacteria populations. These findings suggest that 2′-FL could be developed as a food supplement to help older people maintain better digestive and immune health.

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Interventions targeting the gut-liver axis: A potential treatment strategy for metabolic dysfunction-associated steatotic liver disease

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Your gut bacteria play a crucial role in liver health. When harmful bacteria build up in your gut, they can trigger liver inflammation and fat accumulation, leading to fatty liver disease. Researchers found that simple lifestyle changes like intermittent fasting, eating certain foods that feed good bacteria, and maintaining a healthy diet can restore healthy gut bacteria, strengthen your intestinal barrier, and reduce liver disease. This gut-focused approach could offer new ways to prevent and treat fatty liver disease beyond current treatments.

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A comprehensive overview of the effects of probiotics, prebiotics and synbiotics on the gut-brain axis

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This comprehensive review examines how probiotics (beneficial live bacteria), prebiotics (food for beneficial bacteria), and synbiotics (combinations of both) can influence communication between the gut and brain. These interventions can produce beneficial compounds like GABA and serotonin, strengthen the gut barrier, and reduce inflammation, potentially helping with mood, anxiety, cognition, and various digestive disorders. However, effects vary greatly depending on the specific strain used, dosage, and individual differences in gut bacteria, and more large-scale studies are needed to confirm long-term clinical benefits.

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