Research Keyword: innate immune response

Fusarium Corneal Abscess: A Case Report

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A healthy 20-year-old man developed a serious fungal eye infection caused by Fusarium, a soil fungus, despite having no typical risk factors like eye injury or contact lens wear. Doctors diagnosed the infection through laboratory tests showing fungal filaments and growing the organism in culture. The patient required multiple treatments including antifungal eye drops, injections directly into the cornea, and a graft from amniotic membrane (placenta tissue) to save his vision. The case demonstrates that fungal eye infections can occasionally occur in completely healthy people without obvious causes.

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PTP1B deficiency in myeloid cells increases susceptibility to Candida albicans systemic infection by modulating antifungal immunity

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This research shows that a protein called PTP1B plays an important role in protecting the body against dangerous yeast infections caused by Candida albicans. When this protein is missing from immune cells, mice become much more susceptible to severe fungal infections. The study found that PTP1B helps immune cells called macrophages and neutrophils kill fungi effectively, and when it’s absent, these immune cells work poorly. This discovery suggests that targeting PTP1B could be a new way to help patients fight off serious fungal infections.

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Immunomodulatory activity of Pleurotus pulmonarius crude extract to human monocyte against Cryptococcus neoformans

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This research shows that an extract from the Phoenix oyster mushroom (Pleurotus pulmonarius) can boost the body’s immune cells to fight dangerous fungal infections caused by Cryptococcus neoformans. When immune cells are pre-exposed to this mushroom extract and then encounter the fungus, they become more effective at killing it through increased production of immune-signaling molecules and reactive oxygen species. This natural supplement approach offers a promising alternative to traditional antifungal drugs, which often have significant side effects and can lead to drug resistance.

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Time- and temperature-dependent Pentraxin 3 stability in serum and bronchoalveolar lavage fluid samples

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This study investigated how stable Pentraxin 3 (Ptx3), a protein used to detect fungal infections, remains when stored at different temperatures. Researchers found that Ptx3 stays reliable for up to 8 months in freezer storage at −20°C and even longer at −80°C, making it a dependable biomarker for diagnosing serious fungal infections. However, storing samples at room temperature (37°C) causes the protein to break down quickly, so proper cold storage is essential for accurate test results.

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