inflammatory cytokines

The Molecular Mechanism of Polysaccharides from Polygonatum cyrtonema Hua in Improving Hyperuricemia by Regulating Key Targets of Uric Acid Metabolism in Mice

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This research demonstrates that a traditional Chinese medicinal plant called Polygonatum cyrtonema contains beneficial polysaccharides that can help lower high uric acid levels in the blood, which is a major cause of gout and kidney disease. The study found that these polysaccharides work by reducing the enzyme that produces uric acid and helping the kidneys excrete more of it, while also reducing inflammation. Importantly, this natural treatment protected kidney tissue better than the standard pharmaceutical drug allopurinol, suggesting it could be a safer long-term option for managing high uric acid levels.

Impact of Clove Oil on Biofilm Formation in Candida albicans and Its Effects on Mice with Candida Vaginitis

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This research demonstrates that clove oil, a natural and FDA-approved dietary supplement, can effectively combat Candida albicans infections that cause vaginal yeast infections. The study found that clove oil works by preventing the fungus from forming protective biofilms and by reducing inflammation. In mice with vaginal yeast infections, clove oil treatment significantly improved symptoms and reduced fungal levels, suggesting it could serve as a safer alternative to conventional antifungal medications.

Pathogenic mucorales: Deciphering their cell wall polysaccharidome and immunostimulatory potential

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Mucormycosis is a dangerous fungal infection that kills many immunocompromised patients. Researchers analyzed the outer layer (cell wall) of three common disease-causing fungi and discovered that their surfaces contain sugar-like molecules that trigger strong inflammatory responses from the immune system. This excessive inflammation may actually contribute to the disease’s severity, suggesting that controlling inflammation alongside antifungal treatment might improve patient outcomes.

Polyphenolic Hispolon Derived from Medicinal Mushrooms of the Inonotus and Phellinus Genera Promotes Wound Healing in Hyperglycemia-Induced Impairments

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Researchers tested a natural compound called hispolon, extracted from medicinal mushrooms, to see if it could help heal wounds in diabetic patients. Using both laboratory cells and diabetic rats, they found that hispolon successfully reduced cell damage caused by high blood sugar, improved wound closure, and promoted healthy tissue growth. The compound worked as well as an existing diabetic wound cream and showed no harmful side effects, suggesting it could become a new natural treatment option for diabetic wound complications.

Aspergillus in Children and Young People with Cystic Fibrosis: A Narrative Review

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Cystic fibrosis is a serious genetic disease affecting children that damages the lungs through chronic infections. Aspergillus, a common mold in the environment, colonizes the airways of CF patients and can cause additional lung damage. While new CFTR modulator medications have improved outcomes and reduced Aspergillus infections, more research is needed to better diagnose and treat fungal infections in children with CF.

The P-type calcium pump Spf1 regulates immune response by maintenance of the endoplasmic reticulum-plasma membrane contacts during Candida albicans systemic infection

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A fungal pump protein called Spf1 helps Candida albicans secrete toxins that damage the immune system during infection. When researchers deleted the SPF1 gene, the fungus could not effectively release these toxins, triggering a much weaker immune response and allowing infected mice to survive better. This discovery suggests that controlling this calcium pump could be a new strategy for treating serious fungal infections.

Natural Products in Renal-Associated Drug Discovery

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This research examines how natural products like green tea and medicinal mushrooms can help treat kidney diseases. Scientists reviewed various plants used in traditional medicine and analyzed how compounds from these plants affect gene expression in kidney cells. The study identified specific genes and biological pathways that explain how these natural antioxidants and anti-inflammatory agents protect kidneys from injury and disease.

PTP1B deficiency in myeloid cells increases susceptibility to Candida albicans systemic infection by modulating antifungal immunity

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This research shows that a protein called PTP1B plays an important role in protecting the body against dangerous fungal infections caused by Candida albicans. When mice lacked this protein in their immune cells, they were much more susceptible to the infection and showed severe illness. The study found that PTP1B helps immune cells like macrophages and neutrophils fight the fungus effectively, and blocking this protein could actually make fungal infections worse.

Research Keyword: inflammatory cytokines