Research Keyword: industrial biotechnology

Morphological Engineering of Filamentous Fungi: Research Progress and Perspectives

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Filamentous fungi are microscopic organisms used to produce important enzymes and chemicals in industries. However, their growth forms during fermentation vary significantly and affect product quality. Scientists are developing methods to control how these fungi grow, both by adjusting fermentation conditions like temperature and oxygen levels, and by using genetic engineering to modify their growth patterns. These approaches help improve industrial production of medicines, enzymes, and other useful compounds.

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Enhanced extracellular production of laccase in Coprinopsis cinerea by silencing chitinase gene

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Scientists improved the production of laccase, an enzyme with industrial uses in detoxification and food processing, by genetically engineering mushroom cells to have stronger cell walls. By reducing the activity of genes that break down chitin in the cell wall, they created mushroom strains that could better withstand the stirring forces during fermentation, resulting in over twice as much enzyme production. This breakthrough could lead to cheaper, more efficient production of this useful green catalyst on an industrial scale.

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Engineering Strategies for Fungal Cell Disruption in Biotechnological Applications

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Fungi produce valuable products inside their cells like medicines, oils, and natural colors. However, fungal cell walls are very tough and hard to break open compared to bacteria or algae. Scientists have developed various methods to break open fungal cells, ranging from physical approaches like grinding with beads or using sound waves, to gentler chemical and enzymatic methods. The best method depends on the type of fungus, what product you want to extract, and how much you need to make.

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