immunotherapy – Page 3

The mycelium of the Trametes versicolor synn. Coriolus versicolor (Turkey tail mushroom) exhibit anti-melanoma activity in vitro

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Turkey tail mushrooms, used in traditional Chinese medicine for thousands of years, show promise in fighting melanoma skin cancer. Scientists tested mushroom extracts on melanoma cells in the laboratory and found they kill cancer cells through multiple mechanisms, including triggering programmed cell death and activating the immune system. The mushroom extract also reduced cancer cell migration and showed potential to work better when combined with standard chemotherapy drugs like paclitaxel. These findings suggest turkey tail could be a valuable addition to melanoma treatment strategies.

Active Hexose-Correlated Compound Shows Direct and Indirect Effects against Chronic Lymphocytic Leukemia

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Researchers tested a mushroom-derived supplement called AHCC against chronic lymphocytic leukemia in laboratory and animal studies. AHCC killed leukemia cells directly and also reduced supportive cells in the tumor environment. When combined with antibody therapy, AHCC significantly improved outcomes in mouse models, suggesting it could be a promising addition to current leukemia treatments.

Addressing Patient Requests to Add Dietary Supplements to Their Cancer Care—A Suggested Approach

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Cancer patients often want to use dietary supplements alongside their conventional cancer treatments to manage side effects, boost immunity, and feel more in control of their health. Many patients don’t tell their doctors about supplement use because they worry about judgment or think doctors won’t understand their interests. This paper suggests doctors should have open, non-judgmental conversations with patients about supplements, evaluate their safety and effectiveness using reliable information sources, and work together with patients to make informed decisions that keep them safe while respecting their choices.

Invasive Fungal Disease is Rare in Multiple Myeloma Patients Treated with BCMA CAR-T Therapy

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Researchers studied patients with multiple myeloma who received a new type of cancer treatment called BCMA CAR-T cell therapy. While this powerful therapy can sometimes increase infection risk, the study found that serious fungal infections occurred in only a small percentage of patients (1.7%). However, when these fungal infections did occur, they were often severe and potentially life-threatening, particularly in patients who experienced significant side effects from the therapy.

Cgm1 is a β-galactoside α-(1 → 4)-mannosyltransferase involved in the biosynthesis of capsular glucuronoxylomannogalactan in Cryptococcus neoformans

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Researchers identified a new fungal enzyme called Cgm1 that helps the fungus Cryptococcus neoformans build its protective capsule, which allows it to evade the immune system. When this enzyme is disabled, the fungus becomes weak at body temperature and triggers a stronger immune response in infected mice. Since humans and plants don’t have this enzyme, it could be a promising target for developing new antifungal medications.

Exploring the Anticancer Potential of Coriolus versicolor in Breast Cancer: A Review

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Coriolus versicolor, also known as turkey tail mushroom, has been used in traditional Chinese medicine for thousands of years. Recent scientific research shows it may help fight breast cancer through multiple mechanisms: killing cancer cells directly through programmed cell death pathways, breaking down the estrogen that fuels some breast cancers, preventing cancer spread, and boosting the immune system. While early studies are promising and one clinical trial showed good safety and immune benefits, larger studies are needed before this mushroom can be recommended as an official cancer treatment.

Mushroom Bioactive Molecules as Anticancerous Agents: An Overview

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Mushrooms contain natural compounds that show promise in fighting cancer by triggering cancer cell death and boosting immune function. Different mushroom species like oyster, shiitake, and button mushrooms contain substances such as beta-glucans and other polysaccharides that have demonstrated anticancer properties in laboratory and animal studies. While these mushroom compounds work through multiple mechanisms including preventing new blood vessel formation to tumors and stopping cancer cell division, more human clinical trials are needed to confirm their effectiveness as cancer treatments.

Harnessing Natural Products to Surmount Drug Resistance in Gastric Cancer: Mechanisms and Therapeutic Perspectives

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Gastric cancer is a serious disease that often becomes resistant to chemotherapy drugs, making treatment difficult. This review examines how natural products found in plants and herbs can help overcome this drug resistance. These natural compounds work through multiple mechanisms, including targeting cancer stem cells, boosting the immune system, and enhancing the effectiveness of standard chemotherapy treatments.

Research Keyword: immunotherapy