The C-type lectin receptor Dcir (Clec4a2) restrains Aspergillus fumigatus elimination by limiting the degranulatory activity of neutrophils
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This study reveals that a receptor called Dcir on immune cells called neutrophils actually prevents effective killing of the fungus Aspergillus fumigatus by limiting the release of antibacterial granules. When researchers removed Dcir from mice, their neutrophils became more effective at fighting the fungal infection. This suggests that blocking Dcir might help patients with fungal respiratory infections clear the pathogen more effectively.