immunopathology – mycolab.ai

Corrigendum: Inonotus obliquus (chaga) ameliorates folic acid-induced renal fibrosis in mice: the crosstalk analysis among PT cells, macrophages and T cells based on single-cell sequencing

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This research article, published as a correction, examines how chaga mushroom (Inonotus obliquus) may help treat kidney fibrosis in mice. Using advanced genetic sequencing technology that examines individual cells, scientists identified how chaga works by modulating communication between different immune and kidney cells. The findings suggest that chaga could be a promising natural treatment for progressive kidney disease.

Pathogenic mucorales: Deciphering their cell wall polysaccharidome and immunostimulatory potential

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Scientists studied three types of dangerous fungi that cause serious infections in people with weak immune systems. They looked at the outer coating of these fungi cells, which is what the body’s immune system first encounters during infection. They found that this coating contains multiple types of sugar-like substances that trigger strong inflammatory responses in immune cells. Understanding these fungi better could help develop better treatments for these serious infections.

New insights toward personalized therapies for vulvovaginal candidiasis and vaginal co-infections

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Vaginal yeast infections (vulvovaginal candidiasis) and bacterial vaginosis are very common conditions affecting millions of women worldwide. Current treatments often fail or lead to antibiotic resistance. This review explores new personalized approaches including zinc supplementation, specific probiotics, and immune-boosting therapies that are tailored to each woman’s unique vaginal environment to prevent recurring infections.

Pathogenic mucorales: Deciphering their cell wall polysaccharidome and immunostimulatory potential

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Mucormycosis is a serious fungal infection that primarily affects people with weak immune systems and carries high mortality rates. Researchers studied three common mucormycosis-causing fungi to understand how their outer cell layers interact with the human immune system. They found that all three fungi trigger strong inflammatory responses, which may explain why the disease is so damaging. This research helps us better understand how these infections work and could lead to improved treatments or vaccines.

PTP1B deficiency in myeloid cells increases susceptibility to Candida albicans systemic infection by modulating antifungal immunity

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This research shows that a protein called PTP1B plays an important role in protecting the body against dangerous yeast infections caused by Candida albicans. When this protein is missing from immune cells, mice become much more susceptible to severe fungal infections. The study found that PTP1B helps immune cells called macrophages and neutrophils kill fungi effectively, and when it’s absent, these immune cells work poorly. This discovery suggests that targeting PTP1B could be a new way to help patients fight off serious fungal infections.

PTP1B deficiency in myeloid cells increases susceptibility to Candida albicans systemic infection by modulating antifungal immunity

mycolabadmin

This research shows that a protein called PTP1B plays an important role in protecting the body against dangerous fungal infections caused by Candida albicans. When mice lacked this protein in their immune cells, they were much more susceptible to the infection and showed severe illness. The study found that PTP1B helps immune cells like macrophages and neutrophils fight the fungus effectively, and blocking this protein could actually make fungal infections worse.

One for All and All for One: Multikingdom Interplay in Severe Viral Pneumonia

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This editorial discusses how bacteria, viruses, and fungi interact in the lungs during severe pneumonia from COVID-19 or influenza. When mechanically ventilated patients with COVID-19 had bacterial infections detected, their immune systems released more inflammatory chemicals. However, the same pattern was not observed in influenza patients. Understanding how all these microorganisms work together may help doctors better treat these serious lung infections.

Research Keyword: immunopathology

Corrigendum: Inonotus obliquus (chaga) ameliorates folic acid-induced renal fibrosis in mice: the crosstalk analysis among PT cells, macrophages and T cells based on single-cell sequencing

Pathogenic mucorales: Deciphering their cell wall polysaccharidome and immunostimulatory potential

New insights toward personalized therapies for vulvovaginal candidiasis and vaginal co-infections

Pathogenic mucorales: Deciphering their cell wall polysaccharidome and immunostimulatory potential

PTP1B deficiency in myeloid cells increases susceptibility to Candida albicans systemic infection by modulating antifungal immunity

PTP1B deficiency in myeloid cells increases susceptibility to Candida albicans systemic infection by modulating antifungal immunity

One for All and All for One: Multikingdom Interplay in Severe Viral Pneumonia