immunomodulation – Page 5

Polysaccharides from fungi: A review on their extraction, purification, structural features, and biological activities

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Mushrooms contain special compounds called polysaccharides that have powerful health benefits. Scientists have found these polysaccharides can help fight cancer, boost immunity, reduce inflammation, and manage diabetes. This review explains different ways to extract and purify these beneficial compounds from mushrooms and describes how they work in the body to provide these health benefits.

Airlift bioreactor–based strategies for prolonged semi-continuous cultivation of edible Agaricomycetes

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Scientists studied how to grow medicinal mushrooms in liquid bioreactors to produce health-beneficial compounds called glucans more efficiently. By testing different feeding rates in specially designed fermentation systems, they found that Trametes versicolor (turkey tail mushroom) grows best at a moderate feeding rate, producing substantial amounts of glucans—compounds known to support immune function and reduce blood sugar levels. This research shows that growing medicinal mushrooms in controlled bioreactors could be much more efficient and faster than traditional farming methods.

Bioactive Potential of Tocosh Supplemented with Selenium-Enriched Saccharomyces Cerevisiae Biomass

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Researchers enhanced a traditional Peruvian fermented potato food called tocosh by adding selenium-enriched yeast. This combination reduced inflammation markers in immune cells without affecting its blood sugar impact or antioxidant properties. The resulting product shows promise as a functional food that could help people manage inflammatory conditions while improving nutritional content.

Antioxidant Activity of Mushroom Extracts/Polysaccharides—Their Antiviral Properties and Plausible AntiCOVID-19 Properties

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Mushrooms contain special compounds called polysaccharides that act as natural antioxidants and can fight viruses. These compounds help boost the immune system and reduce inflammation in the body. While mushrooms have shown promise against various viruses including COVID-19, more research is needed to fully develop them as treatments.

Efficacy of PVX and PEGylated PVX as intratumoral immunotherapy

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Researchers developed an improved version of a plant virus particle called potato virus X (PVX) by coating it with polyethylene glycol (PEG) to use as a cancer treatment. When injected directly into tumors, these PVX-PEG particles stimulate the body’s immune system to attack cancer cells. The PEG coating makes the treatment more stable, longer-lasting in tumors, and less likely to be rejected by antibodies from prior exposure to plant viruses, while maintaining its cancer-fighting effectiveness.

Production of β-Glucans by Pleurotus ostreatus: Cultivation and Genetic Background

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Oyster mushrooms (Pleurotus ostreatus) are increasingly popular edible fungi that can grow on various waste materials like agricultural byproducts and food waste, making them both economical and environmentally friendly. These mushrooms produce valuable health-promoting compounds called β-glucans that have immune-boosting and antioxidant properties. Modern scientific techniques, including genetic analysis and artificial intelligence, are being used to optimize cultivation methods and increase production of these beneficial compounds. This sustainable approach to mushroom farming helps reduce waste while providing nutritious and medicinal food products.

Whole genome sequencing and annotations of Trametes sanguinea ZHSJ

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Scientists have completely mapped the genetic code of Trametes sanguinea, a medicinal mushroom used in traditional Chinese medicine. They identified over 10,000 genes and analyzed how this mushroom produces compounds that fight tumors, boost immunity, protect the heart, and fight viruses. This genetic map will help researchers understand how to produce these beneficial compounds and develop new medicines from this mushroom.

The Effect of Natural-Based Formulation (NBF) on the Response of RAW264.7 Macrophages to LPS as an In Vitro Model of Inflammation

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Researchers tested a natural mixture of five medicinal mushrooms combined with cannabidiol (CBD) on immune cells exposed to bacterial endotoxins. The formulation effectively reduced inflammatory response markers without harming the cells. These findings suggest the mixture could potentially be used to treat inflammatory conditions like asthma and arthritis, though more research is needed.

Harnessing the Nutritional Value, Therapeutic Applications, and Environmental Impact of Mushrooms

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Mushrooms are nutritious superfoods packed with protein, fiber, vitamins, and minerals that support overall health. They contain special compounds that can fight inflammation, boost immunity, and help prevent serious diseases like cancer and diabetes. Beyond eating them, mushrooms are being used to make medicines, cosmetics, and animal feed, while also helping clean up polluted environments. Regular consumption of mushrooms offers significant health benefits and can be a valuable addition to any healthy diet.

Anticancer Activity of Demethylincisterol A3 and Related Incisterol-Type Fungal Products

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This review examines a special group of fungal compounds called incisterols, with focus on demethylincisterol A3 (DM-A3), which shows promise as a cancer-fighting agent. DM-A3 works through multiple mechanisms: it blocks cancer cell growth pathways, inhibits specific cancer-promoting proteins, and has anti-inflammatory effects. The compound has shown strong activity against various cancer types in laboratory and animal studies, making it a candidate for further development as a potential cancer therapy.

Research Keyword: immunomodulation