Research Keyword: immunocompromised

Magnusiomyces capitatus bloodstream infection in a patient with acute monocytic leukemia: A rare case report

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A 26-year-old patient with acute leukemia developed a rare fungal bloodstream infection caused by Magnusiomyces capitatus during cancer treatment. The infection was identified through advanced laboratory techniques including DNA sequencing and mass spectrometry. The patient was successfully treated with amphotericin B, highlighting the importance of rapid and accurate fungal identification for better patient outcomes.

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Invasive fungal infections caused by rare yeast-like fungi in adult patients: results of a prospective study

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This study examined rare fungal infections in 30 critically ill adult patients over 18 years, finding that infections caused by uncommon yeasts like Trichosporon and Rhodotorula affected mainly long-term ICU patients with central lines. Despite treatment with antifungal medications, about 37% of patients died, highlighting the serious nature of these infections. The research emphasizes the importance of quickly identifying the specific fungus causing infection and using appropriate medications, along with removing infected catheters, to improve patient survival.

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Co-Infection of Pulmonary Aspergillosis and Cryptococcal Meningitis in an HIV-Positive Patient: A Case Report

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This case describes a 46-year-old man with advanced HIV who developed two serious fungal infections simultaneously: a lung infection caused by Aspergillus fungus and meningitis caused by Cryptococcus fungus. Despite receiving appropriate antifungal medications, his condition worsened and he unfortunately died. The case highlights how people with very low immune cell counts are at high risk for multiple life-threatening fungal infections and emphasizes the importance of early HIV testing and screening for fungal infections.

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Cryptococcal endophthalmitis in a patient with malignancy: A case report and literature review

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A 50-year-old woman with advanced lung cancer developed a rare fungal eye infection caused by Cryptococcus neoformans, resulting in blurred vision. Doctors diagnosed this through eye surgery and fluid analysis, then treated her with strong antifungal medications both injected into the eye and given systemically. After 10 months of treatment, her vision significantly improved, showing that early detection and aggressive antifungal therapy are critical for preventing blindness from this rare infection.

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Clinical, Laboratory, and Biomarker Predictors of 90-Day Mortality in Non-HIV, Non-Transplant Pneumocystis Pneumonia

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This study examined pneumocystis pneumonia in immunocompromised patients who do not have HIV or transplants. Researchers found that older patients with other health conditions were at higher risk of death within 90 days. High levels of fungal markers and low immune cell counts were better predictors of poor outcomes than traditional inflammation markers, suggesting doctors should focus on early identification and personalized treatment approaches.

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Cryptococcus albidus (Naganishia albida) meningitis in a young patient with T-cell acute lymphoblastic leukaemia

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A 16-year-old boy with blood cancer developed meningitis caused by a rare fungus called Cryptococcus albidus. Doctors initially thought he had a viral infection, but laboratory tests identified the fungus. He was treated with antifungal medications and improved significantly. This case shows how important it is to identify the correct cause of infection quickly, especially in patients with weakened immune systems.

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