Research Keyword: immunocompromised hosts

Photo Quiz: A cutaneous fungal infection with discordant biomarker results—a diagnostic challenge

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This case describes a woman with advanced HIV who developed a serious fungal infection called histoplasmosis affecting her skin, lungs, and lymph nodes. Diagnosis was challenging because standard fungal blood tests came back negative, but careful examination of samples and specialized testing confirmed Histoplasma capsulatum. The patient was successfully treated with antifungal medications, highlighting the importance of not relying solely on negative tests when clinical suspicion is high.

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Clinical experience of primary subcutaneous mycoses in Shanghai: a retrospective analysis

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Researchers in Shanghai studied 33 patients with deep skin fungal infections that had become increasingly common in the area. They identified 13 different fungal species causing these infections, most commonly Candida parapsilosis, Trichophyton rubrum, and Sporothrix schenckii. Patients were treated with antifungal medications tailored to the specific fungus and its drug sensitivity, with most patients recovering completely, though some experienced relapses, emphasizing the importance of long-term follow-up care.

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Impact of glycemic control on coccidioidomycosis outcomes in patients with underlying diabetes mellitus in central California

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This study examined how blood sugar control affects outcomes in patients with both diabetes and coccidioidomycosis, a fungal infection common in central California. Researchers found that patients with poorly controlled diabetes (higher HbA1c levels) had higher rates of serious lung disease with cavities and were less likely to recover from the infection. The study highlights that managing blood sugar levels may be just as important as taking antifungal medications when treating this dual condition.

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Trichosporon species bloodstream infections in a tertiary care hospital in the western region of Saudi Arabia: A 7-year retrospective chart review from 2016 to 2022

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This study examined a rare but dangerous fungal infection called Trichosporonosis that affects the bloodstream in hospitalized patients. Researchers found that this infection kills about 60% of patients despite treatment with antifungal medications. The infection is often caused by a fungus called Trichosporon asahii and typically occurs in patients with weakened immune systems who are already hospitalized and using catheters.

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Fungal peritonitis in a patient on peritoneal dialysis caused by Hyphopichia burtonii: A rare pathogen in human infection

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A woman with kidney disease on peritoneal dialysis developed an unusual fungal infection caused by Hyphopichia burtonii, a fungus typically found in spoiled food. The infection was diagnosed using advanced protein analysis technology and treated with antifungal medication after removing the dialysis catheter. Though extremely rare in humans, this case shows that unusual fungi can cause serious infections in patients with weakened immune systems and highlights the importance of considering these organisms when standard treatments don’t work.

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