Research Keyword: immunocompetent patients

The emerging fungal pathogen Cryptococcus gattii: Epidemiology, pathogenesis, immunomodulatory attributes, and drug susceptibility

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Cryptococcus gattii is a dangerous fungal infection that can affect even healthy people, unlike most fungal infections that target those with weak immune systems. The fungus uses clever tricks to hide from the immune system, including creating protective capsules and producing melanin. Current antifungal drugs like fluconazole are becoming less effective as the fungus develops resistance, making this an urgent public health concern that requires better treatments and early detection.

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Disseminated subcutaneous sporotrichosis in an immunocompetent patient: A case report and a systematic literature review

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A 74-year-old man developed multiple infected lumps on his arm, wrist, and finger months after being injured by a tree branch. Doctors identified the infection as sporotrichosis caused by a fungus called Sporothrix schenckii using advanced genetic testing. He was successfully treated with itraconazole tablets for several months and completely recovered. This case is unusual because sporotrichosis typically affects people with weakened immune systems, but this patient had a normal immune system.

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Primary cutaneous mixed infection with Cryptococcus uniguttulatus and Mycobacterium tuberculosis

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A 43-year-old man had persistent facial skin lesions for seven years that initially appeared to be fungal infection caused by Cryptococcus uniguttulatus. Standard antifungal treatments failed to completely cure the condition. Advanced genetic testing revealed the lesions were actually caused by two simultaneous infections: the fungus and tuberculosis bacteria. Once both infections were properly identified and treated with appropriate medications, the skin lesions finally healed.

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Fungal Sinusitis Spreading to the Sellar Region Mimicking a Pituitary Tumor: Case Report and Literature Review

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A 56-year-old woman was found to have a large mass in her sinus cavity that had eroded bone and spread to the area around her pituitary gland, mimicking a pituitary tumor. Through surgery and pathological examination, doctors discovered it was actually a fungal infection (fungus ball) rather than a tumor. This case report reviews 67 similar patients from medical literature to help doctors better recognize and treat these rare fungal infections that can threaten vision and endocrine function.

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